Peripheral nerve injury increases contribution of L-type calcium channels to synaptic transmission in spinal lamina II: Role of α2δ–1 subunits

• Published in: Molecular pain Vol. 14; p. 1744806918765806
• Main Authors: Alles, Sascha RA, Garcia, Esperanza, Balasubramanyan, Sridhar, Jones, Karen, Tyson, John R, Joy, Twinkle, Snutch, Terrance P, Smith, Peter A
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2018; Sage Publications Ltd
• Subjects: Calcium channels; Calcium channels (L-type); Calcium channels (voltage-gated); Calcium influx; Dihydropyridine; Dorsal horn; Excitatory postsynaptic potentials; Gabapentin; Neurons; Neurotransmitter release; Oocytes; Peripheral nerves; Peripheral neuropathy; Sensory neurons; Synaptic transmission; Allodynia; neuropathic pain; gabapentin; substantia gelatinosa; calcium channel blocker; pharmacology; anti-allodynic; chronic constriction injury; central sensitization; dihydropyridine

Background Following peripheral nerve chronic constriction injury, the accumulation of the α2δ–1 auxiliary subunit of voltage-gated Ca2+ channels in primary afferent terminals contributes to the onset of neuropathic pain. Overexpression of α2δ–1 in Xenopus oocytes increases the opening properties of...