National survey of bladder endometriosis cases in Japan

• Published in: The journal of obstetrics and gynaecology research Vol. 47; no. 4; pp. 1451 - 1461
• Main Authors: Hirata, Tetsuya, Koga, Kaori, Taniguchi, Fuminori, Takazawa, Naoko, Honda, Ritsuo, Tanaka, Toshiaki, Kurihara, Masatoshi, Nakajima, Jun, Yoshimura, Kotaro, Kitade, Mari, Narahara, Hisashi, Kitawaki, Jo, Harada, Tasuku, Katabuchi, Hidetaka, Horie, Shigeo, Osuga, Yutaka
• Format: Journal Article
• Language: English
• Published: Kyoto, Japan John Wiley & Sons Australia, Ltd 01.04.2021; Wiley Subscription Services, Inc
• Subjects: bladder endometriosis; Body mass index; Endometriosis; Gonadotropin-releasing hormone; Laparoscopy; national survey; partial cystectomy; Patients; recurrence; Renal function; Statistical analysis; Surgery; transurethral resection; Ureter; Japan; recurrence; partial cystectomy; bladder endometriosis; national survey; transurethral resection
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.14656

Aim We aimed to describe the clinical presentation, operative or medical management, and postoperative recurrence of bladder endometriosis (BE). Methods We conducted a national survey to investigate BE cases from 2006 to 2016 in Japan. Histologically diagnosed cases were extracted and then investigated for the following factors: age at diagnosis, body mass index, symptoms, imaging modalities, surgical therapy, hormonal therapy, follow‐up period, and postoperative recurrence. Results Eighty‐nine patients with pathologically benign BE were identified. Eighty patients underwent surgery, whereas nine did not. Moreover, 34 and 44 patients underwent transurethral resection (TUR) and partial cystectomy (PC), respectively. Cumulative recurrence rates were significantly higher with TUR than with PC (p < 0.05). The recurrence rate tended to be higher after laparoscopic PC (n = 24) than after open PC (n = 20), but the difference was not statistically significant (p = 0.0879). Of the nine nonsurgical patients, eight received hormonal therapy and one did not. Efficacy rates of dienogest, GnRH agonist, and OC were 85.7%, 66.7%, and 66.7%, respectively. Of five patients with BE extending to the ureter or ureteral orifices, two underwent PC and ureteroneocystostomy and one underwent total nephroureterectomy due to renal function loss. Conclusion To our knowledge, this is the first study to compare the postoperative recurrence of BE after TUR and PC. We found that cumulative recurrence rate is significantly lower after PC than after TUR. BE extending to the ureter or ureteral orifices is a very challenging condition. Further studies are required for the optimal management of BE.