Prognostic factors for soft tissue sarcoma patients with lung metastases only who are receiving first‐line chemotherapy: An exploratory, retrospective analysis of the European Organization for Research and Treatment of Cancer‐Soft Tissue and Bone Sarcoma Group (EORTC‐STBSG)

• Published in: International journal of cancer Vol. 142; no. 12; pp. 2610 - 2620
• Main Authors: Lindner, Lars H., Litière, Saskia, Sleijfer, Stefan, Benson, Charlotte, Italiano, Antoine, Kasper, Bernd, Messiou, Christina, Gelderblom, Hans, Wardelmann, Eva, Le Cesne, Axel, Blay, Jean‐Yves, Marreaud, Sandrine, Hindi, Nadia, Desar, Ingrid M.E., Gronchi, Alessandro, van der Graaf, Winette T.A.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 15.06.2018; John Wiley and Sons Inc
• Subjects: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bone cancer; Bone tumors; Cancer; Cancer Therapy and Prevention; Chemotherapy; Datasets as Topic; Decision making; Diagnosis; EORTC; Factor analysis; Female; Humans; Kaplan-Meier Estimate; Lung cancer; lung metastases; Lung Neoplasms - drug therapy; Lung Neoplasms - mortality; Lung Neoplasms - secondary; Lungs; Male; Medical prognosis; Medical research; Metastases; Metastasis; Middle Aged; Neoplasm Metastasis - pathology; Patients; Prognosis; prognostic factors; Progression-Free Survival; Proportional Hazards Models; Pulmonary lesions; Retrospective Studies; Sarcoma; Sarcoma - drug therapy; Sarcoma - mortality; Sarcoma - secondary; Soft Tissue Neoplasms - drug therapy; Soft Tissue Neoplasms - mortality; Soft Tissue Neoplasms - pathology; Soft tissue sarcoma; prognostic factors; soft tissue sarcoma; EORTC; lung metastases
• ISSN: 0020-7136; 1097-0215; 1097-0215
• DOI: 10.1002/ijc.31286

The prognosis of adult soft tissue sarcoma (STS) patients with metastases is generally poor. As little is known about the impact of the involvement of different metastatic sites and the extent of pulmonary lesions on the outcome for patients receiving first‐line chemotherapy, we aimed to establish prognostic factors for STS patients with lung metastases only. A retrospective, exploratory analysis was performed on 2,913 metastatic STS patients who received first‐line chemotherapy. Detailed information from 580 patients who had lung metastases only, was used for prognostic factor analysis. Patients with lung metastases only were more often asymptomatic and had undergone complete primary tumor resection more frequently compared to patients with additional metastases outside the lung or without lung metastases. For extremity STS, the incidence of lung metastases only was much higher compared to non‐extremity STS. Lung involvement only was an independent favorable prognostic factor for overall survival (OS) with regard to metastatic site. Within this subgroup, in a multivariate model, other factors associated with improved OS included: good performance status (PS), no progression at primary site, low histological grade, younger age, long interval between initial diagnosis and trial registration, and smaller diameter of the largest lung lesion. This unique analysis on prognostic factors in STS patients with lung metastases confirms well‐known patient factors (such as age and PS), and tumor characteristics (including tumor grade, interval between primary diagnosis, and metastases), but also identifies diameter of the largest lung lesion as a new prognostic factor. Knowledge about these factors may support decision‐making within multidisciplinary tumor boards. What's new? About 25% of soft tissue sarcoma patients develop lung metastases but prognostic factors for those who cannot get operated remain scarce. Here the authors performed a retrospective study of datasets obtained from 580 patients where metastases have not spread beyond the lung and who received first‐line chemotherapy but no resection. Interestingly, the largest diameter of a lung lesion emerged as a new prognostic factor, a finding, which may influence clinical decisions in the future.