Circadian regulation in the retina: From molecules to network

• Published in: The European journal of neuroscience Vol. 51; no. 1; pp. 194 - 216
• Main Author: Ko, Gladys Y.‐P.
• Format: Journal Article
• Language: English
• Published: France Wiley Subscription Services, Inc 01.01.2020
• Subjects: Adenosine; Circadian rhythm; Circadian rhythms; Diurnal; Dopamine; Epithelium; Gap junctions; Melatonin; Oscillators; photoreceptor; Retina; Retinal pigment epithelium; retina; circadian rhythm; photoreceptor
• ISSN: 0953-816X; 1460-9568
• DOI: 10.1111/ejn.14185

The mammalian retina is the most unique tissue among those that display robust circadian/diurnal oscillations. The retina is not only a light sensing tissue that relays light information to the brain, it has its own circadian “system” independent from any influence from other circadian oscillators. While all retinal cells and retinal pigment epithelium (RPE) possess circadian oscillators, these oscillators integrate by means of neural synapses, electrical coupling (gap junctions), and released neurochemicals (such as dopamine, melatonin, adenosine, and ATP), so the whole retina functions as an integrated circadian system. Dysregulation of retinal clocks not only causes retinal or ocular diseases, it also impacts the circadian rhythm of the whole body, as the light information transmitted from the retina entrains the brain clock that governs the body circadian rhythms. In this review, how circadian oscillations in various retinal cells are integrated, and how retinal diseases affect daily rhythms. The vertebrate retina is the most unique tissue among those that display robust circadian rhythms, because it is a light sensing tissue that can “know” time through detecting the ambient illumination, but its own “circadian system” prepares the retina ready to anticipate the upcoming down or dusk. This review provides an overview on how circadian oscillations in various retinal cells are integrated, and how retinal diseases might affect daily rhythms.