Therapeutic potentials and modulatory mechanisms of fatty acids in bone

Bone metabolism is a lifelong process that includes bone formation and resorption. Osteoblasts and osteoclasts are the predominant cell types associated with bone metabolism, which is facilitated by other cells such as bone marrow mesenchymal stem cells (BMMSCs), osteocytes and chondrocytes. As an i...

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Published inCell proliferation Vol. 53; no. 2; pp. e12735 - n/a
Main Authors Bao, Minyue, Zhang, Kaiwen, Wei, Yangyini, Hua, Weihan, Gao, Yanzi, Li, Xin, Ye, Ling
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.02.2020
John Wiley and Sons Inc
Subjects
Animals
Biomedical materials
Bone and Bones - metabolism
Bone diseases
Bone growth
bone homeostasis
Bone marrow
bone metabolism
Bone resorption
Bone turnover
Cartilage
Chemical compounds
Chemokines
Chondrocytes
Disease prevention
Disorders
Energy Metabolism - physiology
Fatty acids
Fatty Acids - metabolism
Fibroblasts
Fractures
Human subjects
Humans
Mesenchymal Stem Cells - metabolism
Mesenchyme
Metabolism
Metabolites
Neutrophils
Osteoblasts
Osteoblasts - metabolism
Osteoclasts
Osteoclasts - metabolism
Osteocytes
Osteogenesis
Osteogenesis - physiology
Osteoporosis
Pharmacology
Polyunsaturated fatty acids
Review
Reviews
Rheumatoid arthritis
Stem cells
Tumor necrosis factor-TNF
bone homeostasis
bone diseases
bone metabolism
fatty acids
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Abstract Bone metabolism is a lifelong process that includes bone formation and resorption. Osteoblasts and osteoclasts are the predominant cell types associated with bone metabolism, which is facilitated by other cells such as bone marrow mesenchymal stem cells (BMMSCs), osteocytes and chondrocytes. As an important component in our daily diet, fatty acids are mainly categorized as long‐chain fatty acids including polyunsaturated fatty acids (LCPUFAs), monounsaturated fatty acids (LCMUFAs), saturated fatty acids (LCSFAs), medium‐/short‐chain fatty acids (MCFAs/SCFAs) as well as their metabolites. Fatty acids are closely associated with bone metabolism and associated bone disorders. In this review, we summarized the important roles and potential therapeutic implications of fatty acids in multiple bone disorders, reviewed the diverse range of critical effects displayed by fatty acids on bone metabolism, and elucidated their modulatory roles and mechanisms on specific bone cell types. The evidence supporting close implications of fatty acids in bone metabolism and disorders suggests fatty acids as potential therapeutic and nutritional agents for the treatment and prevention of metabolic bone diseases.
AbstractList Bone metabolism is a lifelong process that includes bone formation and resorption. Osteoblasts and osteoclasts are the predominant cell types associated with bone metabolism, which is facilitated by other cells such as bone marrow mesenchymal stem cells (BMMSCs), osteocytes and chondrocytes. As an important component in our daily diet, fatty acids are mainly categorized as long‐chain fatty acids including polyunsaturated fatty acids (LCPUFAs), monounsaturated fatty acids (LCMUFAs), saturated fatty acids (LCSFAs), medium‐/short‐chain fatty acids (MCFAs/SCFAs) as well as their metabolites. Fatty acids are closely associated with bone metabolism and associated bone disorders. In this review, we summarized the important roles and potential therapeutic implications of fatty acids in multiple bone disorders, reviewed the diverse range of critical effects displayed by fatty acids on bone metabolism, and elucidated their modulatory roles and mechanisms on specific bone cell types. The evidence supporting close implications of fatty acids in bone metabolism and disorders suggests fatty acids as potential therapeutic and nutritional agents for the treatment and prevention of metabolic bone diseases.
Bone metabolism is a lifelong process that includes bone formation and resorption. Osteoblasts and osteoclasts are the predominant cell types associated with bone metabolism, which is facilitated by other cells such as bone marrow mesenchymal stem cells (BMMSCs), osteocytes and chondrocytes. As an important component in our daily diet, fatty acids are mainly categorized as long-chain fatty acids including polyunsaturated fatty acids (LCPUFAs), monounsaturated fatty acids (LCMUFAs), saturated fatty acids (LCSFAs), medium-/short-chain fatty acids (MCFAs/SCFAs) as well as their metabolites. Fatty acids are closely associated with bone metabolism and associated bone disorders. In this review, we summarized the important roles and potential therapeutic implications of fatty acids in multiple bone disorders, reviewed the diverse range of critical effects displayed by fatty acids on bone metabolism, and elucidated their modulatory roles and mechanisms on specific bone cell types. The evidence supporting close implications of fatty acids in bone metabolism and disorders suggests fatty acids as potential therapeutic and nutritional agents for the treatment and prevention of metabolic bone diseases.Bone metabolism is a lifelong process that includes bone formation and resorption. Osteoblasts and osteoclasts are the predominant cell types associated with bone metabolism, which is facilitated by other cells such as bone marrow mesenchymal stem cells (BMMSCs), osteocytes and chondrocytes. As an important component in our daily diet, fatty acids are mainly categorized as long-chain fatty acids including polyunsaturated fatty acids (LCPUFAs), monounsaturated fatty acids (LCMUFAs), saturated fatty acids (LCSFAs), medium-/short-chain fatty acids (MCFAs/SCFAs) as well as their metabolites. Fatty acids are closely associated with bone metabolism and associated bone disorders. In this review, we summarized the important roles and potential therapeutic implications of fatty acids in multiple bone disorders, reviewed the diverse range of critical effects displayed by fatty acids on bone metabolism, and elucidated their modulatory roles and mechanisms on specific bone cell types. The evidence supporting close implications of fatty acids in bone metabolism and disorders suggests fatty acids as potential therapeutic and nutritional agents for the treatment and prevention of metabolic bone diseases.
Author Hua, Weihan
Zhang, Kaiwen
Bao, Minyue
Gao, Yanzi
Ye, Ling
Wei, Yangyini
Li, Xin
AuthorAffiliation 2 State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases Department of Cariology and Endodontics West China Hospital of Stomatology Sichuan University Chengdu China
1 State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China
AuthorAffiliation_xml – name: 2 State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases Department of Cariology and Endodontics West China Hospital of Stomatology Sichuan University Chengdu China
– name: 1 State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China
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  surname: Bao
  fullname: Bao, Minyue
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– sequence: 2
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  surname: Zhang
  fullname: Zhang, Kaiwen
  organization: Sichuan University
– sequence: 3
  givenname: Yangyini
  surname: Wei
  fullname: Wei, Yangyini
  organization: Sichuan University
– sequence: 4
  givenname: Weihan
  surname: Hua
  fullname: Hua, Weihan
  organization: Sichuan University
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  givenname: Yanzi
  surname: Gao
  fullname: Gao, Yanzi
  organization: Sichuan University
– sequence: 6
  givenname: Xin
  orcidid: 0000-0002-2521-2099
  surname: Li
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  organization: Sichuan University
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  givenname: Ling
  surname: Ye
  fullname: Ye, Ling
  email: yeling@scu.edu.cn
  organization: Sichuan University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31797479$$D View this record in MEDLINE/PubMed
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2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 2
Keywords bone homeostasis
bone diseases
bone metabolism
fatty acids
Language English
License Attribution
2019 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Snippet Bone metabolism is a lifelong process that includes bone formation and resorption. Osteoblasts and osteoclasts are the predominant cell types associated with...
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SubjectTerms Animals
Biomedical materials
Bone and Bones - metabolism
Bone diseases
Bone growth
bone homeostasis
Bone marrow
bone metabolism
Bone resorption
Bone turnover
Cartilage
Chemical compounds
Chemokines
Chondrocytes
Disease prevention
Disorders
Energy Metabolism - physiology
Fatty acids
Fatty Acids - metabolism
Fibroblasts
Fractures
Human subjects
Humans
Mesenchymal Stem Cells - metabolism
Mesenchyme
Metabolism
Metabolites
Neutrophils
Osteoblasts
Osteoblasts - metabolism
Osteoclasts
Osteoclasts - metabolism
Osteocytes
Osteogenesis
Osteogenesis - physiology
Osteoporosis
Pharmacology
Polyunsaturated fatty acids
Review
Reviews
Rheumatoid arthritis
Stem cells
Tumor necrosis factor-TNF
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Title Therapeutic potentials and modulatory mechanisms of fatty acids in bone
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Volume 53
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