Therapeutic potentials and modulatory mechanisms of fatty acids in bone

• Published in: Cell proliferation Vol. 53; no. 2; pp. e12735 - n/a
• Main Authors: Bao, Minyue, Zhang, Kaiwen, Wei, Yangyini, Hua, Weihan, Gao, Yanzi, Li, Xin, Ye, Ling
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2020; John Wiley and Sons Inc
• Subjects: Animals; Biomedical materials; Bone and Bones - metabolism; Bone diseases; Bone growth; bone homeostasis; Bone marrow; bone metabolism; Bone resorption; Bone turnover; Cartilage; Chemical compounds; Chemokines; Chondrocytes; Disease prevention; Disorders; Energy Metabolism - physiology; Fatty acids; Fatty Acids - metabolism; Fibroblasts; Fractures; Human subjects; Humans; Mesenchymal Stem Cells - metabolism; Mesenchyme; Metabolism; Metabolites; Neutrophils; Osteoblasts; Osteoblasts - metabolism; Osteoclasts; Osteoclasts - metabolism; Osteocytes; Osteogenesis; Osteogenesis - physiology; Osteoporosis; Pharmacology; Polyunsaturated fatty acids; Review; Reviews; Rheumatoid arthritis; Stem cells; Tumor necrosis factor-TNF; bone homeostasis; bone diseases; bone metabolism; fatty acids
• ISSN: 0960-7722; 1365-2184; 1365-2184
• DOI: 10.1111/cpr.12735

Bone metabolism is a lifelong process that includes bone formation and resorption. Osteoblasts and osteoclasts are the predominant cell types associated with bone metabolism, which is facilitated by other cells such as bone marrow mesenchymal stem cells (BMMSCs), osteocytes and chondrocytes. As an important component in our daily diet, fatty acids are mainly categorized as long‐chain fatty acids including polyunsaturated fatty acids (LCPUFAs), monounsaturated fatty acids (LCMUFAs), saturated fatty acids (LCSFAs), medium‐/short‐chain fatty acids (MCFAs/SCFAs) as well as their metabolites. Fatty acids are closely associated with bone metabolism and associated bone disorders. In this review, we summarized the important roles and potential therapeutic implications of fatty acids in multiple bone disorders, reviewed the diverse range of critical effects displayed by fatty acids on bone metabolism, and elucidated their modulatory roles and mechanisms on specific bone cell types. The evidence supporting close implications of fatty acids in bone metabolism and disorders suggests fatty acids as potential therapeutic and nutritional agents for the treatment and prevention of metabolic bone diseases.