The effect of chronic nausea on gastric slow wave spatiotemporal dynamics in children

• Published in: Neurogastroenterology and motility Vol. 33; no. 5; pp. e14035 - n/a
• Main Authors: Somarajan, Suseela, Muszynski, Nicole D., Olson, Joseph D., Comstock, Andrew, Russell, Alexandra C., Walker, Lynn S., Acra, Sari A., Bradshaw, Leonard A.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2021
• Subjects: Adolescent; Case-Control Studies; Child; Chronic Disease; chronic nausea; Decision making; Electrodiagnosis; electrogastrogram; Electrophysiological Phenomena - physiology; Female; gastric slow wave; Gastrointestinal diseases; Gastrointestinal Motility - physiology; Humans; Male; Nausea; Nausea - physiopathology; Patients; pediatrics; Postprandial Period; Propagation; Quality of life; Stomach - physiopathology; electrogastrogram; chronic nausea; gastric slow wave; pediatrics
• ISSN: 1350-1925; 1365-2982
• DOI: 10.1111/nmo.14035

Background Chronic nausea in adolescents with functional gastrointestinal disorders is an increasingly reported but poorly understood symptom that negatively affects quality of life. Functional gastrointestinal disorders are known to correlate closely with slow wave rhythm disturbances. The ability to characterize gastric electrophysiologic perturbations in functional nausea patients could provide potential diagnostic and therapeutic tools for nausea patients. Methods We used high‐resolution electrogastrograms (HR‐EGG) to measure gastric slow wave parameters in pediatric chronic nausea patients and healthy subjects both pre‐ and postprandial. We computed the dominant frequency, percentage power distribution, gastric slow wave propagation direction, and speed from HR‐EGG. Key Results We observed significant differences in the dominant frequency and power distributed in normal and bradyarrhythmia frequency ranges when comparing patients and healthy subjects. Propagation patterns in healthy subjects were predominantly anterograde, while patients exhibited a variety of abnormalities including retrograde, anterograde, and disrupted patterns. There was a significant difference in the preprandial mean slow wave direction between healthy subjects (222° ± 22°) and patients (103° ± 66°; p ˂ 0.01), although the postprandial mean direction between healthy subjects and patients was similar (p = 0.73). No significant difference in slow wave propagation speed was found between patients and healthy subjects in either pre‐ (p = 0.21) or postprandial periods (p = 0.75). Conclusions and Inferences The spatiotemporal characterization of gastric slow wave activity using HR‐EGG distinguishes symptomatic chronic nausea patients from healthy subjects. This characterization may in turn inform and direct clinical decision‐making and lead to further insight into its pathophysiology. Spatiotemporal gastric slow wave parameters determined from the high resolution electrogastrograms (HR‐EGG) distinguished pediatric chronic nausea patients from healthy subjects. HR‐EGG may substantially advance the ability to characterize functional gastric disorders noninvasively in the pediatric clinic.