Safe, rapid administration schedule for cis-platinum-mannitol

Cis-diamminedichloroplatinum (II) cis-plastinum, 25--75 mg/m2, with 40 gm mannitol and fluid were given over 1--2 hours to 40 patients with no evidence of elevated serum creatinine levels. Cis-plantinum was administered every 28 days at a dose of 50 mg/m2 to 22 patients, and 75mg/m2 to 6 patients. P...

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Bibliographic Details
Published inMedical and pediatric oncology Vol. 4; no. 4; p. 371
Main Authors Rainey, J M, Alberts, D S
Format Journal Article
LanguageEnglish
Published United States 1978
Subjects
Adult
Aged
Cisplatin - administration & dosage
Cisplatin - adverse effects
Creatinine - blood
Drug Administration Schedule
Drug Therapy, Combination
Female
Humans
Kidney Tubular Necrosis, Acute - prevention & control
Male
Mannitol - administration & dosage
Middle Aged
Neoplasms - blood
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Summary:Cis-diamminedichloroplatinum (II) cis-plastinum, 25--75 mg/m2, with 40 gm mannitol and fluid were given over 1--2 hours to 40 patients with no evidence of elevated serum creatinine levels. Cis-plantinum was administered every 28 days at a dose of 50 mg/m2 to 22 patients, and 75mg/m2 to 6 patients. Patients received from one to eight courses of therapy with no change in their serum creatinine level. A safe, simple method of cis-platinum administration has been achieved.
ISSN:0098-1532
DOI:10.1002/mpo.2950040415