FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder

• Published in: Movement disorders Vol. 32; no. 10; pp. 1482 - 1486
• Main Authors: Meles, Sanne K., Vadasz, David, Renken, Remco J., Sittig‐Wiegand, Elisabeth, Mayer, Geert, Depboylu, Candan, Reetz, Kathrin, Overeem, Sebastiaan, Pijpers, Angelique, Reesink, Fransje E., van Laar, Teus, Heinen, Lisette, Teune, Laura K., Höffken, Helmut, Luster, Marcus, Kesper, Karl, Adriaanse, Sofie M., Booij, Jan, Leenders, Klaus L., Oertel, Wolfgang H.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2017; John Wiley and Sons Inc
• Subjects: 18F‐FDG‐PET; Aged; Analysis of Variance; Behavior disorders; Brief Report; Brief Reports; Cross-Sectional Studies; Dementia; Dementia disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins - metabolism; Dopamine transporter; dopamine transporter 123I‐FP‐CIT SPECT; Female; Fluorodeoxyglucose F18; Humans; idiopathic REM sleep behavior disorder; Lewy bodies; Lewy Body Disease - diagnostic imaging; Male; Middle Aged; Movement disorders; Neurodegenerative diseases; Neuroimaging; Olfaction; Olfaction Disorders - diagnostic imaging; Olfaction Disorders - etiology; Parkinson Disease - diagnostic imaging; Parkinson's disease; Parkinson's disease‐related pattern; Positron emission tomography; Psychiatric Status Rating Scales; REM sleep; REM Sleep Behavior Disorder - complications; REM Sleep Behavior Disorder - diagnostic imaging; REM Sleep Behavior Disorder - metabolism; Single photon emission computed tomography; Sleep; Sleep disorders; Tomography, Emission-Computed, Single-Photon; olfaction; idiopathic REM sleep behavior disorder; 18F-FDG-PET; Parkinson's disease-related pattern; dopamine transporter 123I-FP-CIT SPECT
• ISSN: 0885-3185; 1531-8257; 1531-8257
• DOI: 10.1002/mds.27094

ABSTRACT Background Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD‐related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD‐related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder. Methods In this cross‐sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent 18F‐fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included 18F‐fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with dementia with Lewy bodies. PD‐related pattern expression z‐scores were computed from all PET scans. Results PD‐related pattern expression was higher in idiopathic REM sleep behavior disorder subjects compared with controls (P = 0.048), but lower compared with PD (P = 0.001) and dementia with Lewy bodies (P < 0.0001). PD‐related pattern expression was higher in idiopathic REM sleep behavior disorder subjects with hyposmia and in subjects with an abnormal dopamine transporter scan (P < 0.05, uncorrected). Conclusion PD‐related pattern expression, dopamine transporter binding, and olfaction may provide complementary information for predicting phenoconversion. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.