Gene/environment interactions in craniosynostosis: A brief review

It is suggested that craniosynostosis is caused by a heterogeneous set of effects including gene mutations, teratogenic exposure during critical periods of development and gene/environment interactions. Distinguishing between sufficient, additive and interactive effects is important to the study of...

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Bibliographic Details
Published inOrthodontics & craniofacial research Vol. 20; no. S1; pp. 8 - 11
Main Authors Durham, E. L., Howie, R. N., Cray, J. J.
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.06.2017
Subjects
Animal Modeling
Cranial sutures
Craniosynostoses - etiology
Craniosynostoses - genetics
Craniosynostosis
Dentistry
Gene-Environment Interaction
Gene/Environment Interactions
Genotype & phenotype
Humans
Mutation
Phenotype
Teratogenicity
Animal Modeling
Gene/Environment Interactions
Craniosynostosis
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Summary:It is suggested that craniosynostosis is caused by a heterogeneous set of effects including gene mutations, teratogenic exposure during critical periods of development and gene/environment interactions. Distinguishing between sufficient, additive and interactive effects is important to the study of gene/environment interactions and allows for segregation of environmental exposures effecting susceptible populations. Through the identification of sufficient and interactive effects, efforts in prevention of craniosynostosis may be successful. Here, we provide a brief review focusing on defining these categorized exposures and relevant literature that has interrogated gene/environment interactions for craniosynostosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1601-6335
1601-6343
DOI:10.1111/ocr.12153