Cardiac magnetic resonance feature tracking of the right ventricle in convalescent Kawasaki disease in a large single center

• Published in: Clinical cardiology (Mahwah, N.J.) Vol. 44; no. 1; pp. 108 - 115
• Main Authors: Yao, Qiong, Hu, Xi‐hong, He, Li‐li
• Format: Journal Article
• Language: English
• Published: New York Wiley Periodicals, Inc 01.01.2021; John Wiley & Sons, Inc
• Subjects: Aneurysms; Blood clots; Cardiac function; cardiac magnetic resonance; Clinical Investigations; coronary artery aneurysm; Coronary vessels; Ejection fraction; feature tracking; Heart; Kawasaki disease; myocardial fibrosis; Patients; Software; Statistical analysis; Thrombosis; Veins & arteries; coronary artery aneurysm; feature tracking; Kawasaki disease; thrombosis; cardiac magnetic resonance; myocardial fibrosis
• ISSN: 0160-9289; 1932-8737
• DOI: 10.1002/clc.23512

Background The changes in right ventricular (RV) contractility of Kawasaki disease (KD) still remain unclear. Hypothesis We aimed to determine whether RV systolic dysfunction can be detected by cardiac magnetic resonance (CMR) feature tracking and to find its association with coronary artery lesions (aneurysm, thrombosis and stenosis). Methods Peak systolic myocardial longitudinal, radial and circumferential strain and the strain rate (RVSL, RVSR, RVSC, RVSRL, RVSRR and RVSRC) in the global RV and three levels (basal, middle and apical) were measured in 66 patients with convalescent KD. A total of 20 controls were included. Comparisons were made with controls and among KD subgroups divided with coronary artery lesions. Results RVSC (−10.575% vs. −10.760%), RVSL (−18.150% vs. −18.712%) and RVSRC (−0.815/s vs. −0.924/s) were slightly lower in KD group without significant difference. All the strain and strain rate presented lowest in the basal level. In subgroup comparison, lower RVSL and RVSRL were observed in the giant coronary artery aneurysm (CAA) group; RVSR (15.844% vs. 16.897%), RVSRR (1.245/s vs. 1.322/s) and RVSRC (−0.715/s vs. −0.895/s) were lower in thrombosed group; RVSRL (−1.27/s vs. −1.503/s) were lower in stenosis group. All the comparison in subgroups did not reach significant difference. From the analysis of receiver operating characteristic curve, RVSRL had a better ability to identify KD with giant CAA and stenosis. For the identification of thrombosis, RVSRC had a better ability. Conclusions Lower strain and strain rates of RV were detected in convalescent KD. More pronounced in those with persisting coronary artery lesions.