Oxidative Trifluoromethylation of Arylboronates with Shelf-Stable Potassium (Trifluoromethyl)trimethoxyborate

Introducing CF3: Arylboronic acid pinacol esters are converted into the corresponding benzotrifluorides with the easy‐to‐use one‐component trifluoromethylating reagent potassium (trifluoromethyl)trimethoxyborate, mediated by copper acetate under an oxygen atmosphere (see scheme).

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Bibliographic Details
Published inChemistry : a European journal Vol. 18; no. 6; pp. 1577 - 1581
Main Authors Khan, Bilal A., Buba, Annette E., Gooßen, Lukas J.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 06.02.2012
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Acetates
Atmospheres
benzotrifluorides
boronic acids
Boronic Acids - chemistry
Chemistry
Chemistry, Multidisciplinary
Copper
Copper - chemistry
Copper converters
CC coupling
Dimethyl Sulfoxide - chemistry
Esters
Fluorobenzenes - chemistry
Organic chemistry
Oxidation-Reduction
Palladium - chemistry
Physical Sciences
Potassium
Reagents
Science & Technology
trifluoromethylation
benzotrifluorides
CROSS-COUPLING REACTION
CONVENIENT METHOD
REDUCTIVE ELIMINATION
AROMATIC-COMPOUNDS
C?C coupling
MEDICINAL CHEMISTRY
COPPER-CATALYZED TRIFLUOROMETHYLATION
copper
trifluoromethylation
IN-SITU
boronic acids
CARBOXYLIC-ACIDS
BOND-FORMATION
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Summary:Introducing CF3: Arylboronic acid pinacol esters are converted into the corresponding benzotrifluorides with the easy‐to‐use one‐component trifluoromethylating reagent potassium (trifluoromethyl)trimethoxyborate, mediated by copper acetate under an oxygen atmosphere (see scheme).
Bibliography:Landesgraduiertenstiftung
DFG - No. SFB-TRR 88
istex:63AC15F2CB9CEE34997FAFD495CCBF8D9D32088B
NanoKat
HEC Pakistan
ArticleID:CHEM201102652
ark:/67375/WNG-BDZK1Z7V-9
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201102652