Cold aggravates abnormal excitability of motor axons in oxaliplatin‐treated patients

• Published in: Muscle & nerve Vol. 61; no. 6; pp. 796 - 800
• Main Authors: Bennedsgaard, Kristine, Ventzel, Lise, Grafe, Peter, Tigerholm, Jenny, Themistocleous, Andreas C., Bennett, David L., Tankisi, Hatice, Finnerup, Nanna B.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.06.2020; Wiley Subscription Services, Inc
• Subjects: allodynia; Axons; Channel gating; Clinical Research Short Report; Clinical Research Short Reports; Cold; Colorectal cancer; Colorectal carcinoma; Cooling; Cooling effects; Excitability; Motor neurons; nerve excitability testing; neuropathy; Oxaliplatin; oxaliplatin toxicity; Pain; Pain perception; Peripheral nerves; Potassium; potassium channel dysfunction; Potassium channels; Potassium channels (voltage-gated); Refractory period; Sensory testing; Skin temperature; sodium channel dysfunction; Sodium channels (voltage-gated); neuropathy; allodynia; nerve excitability testing; sodium channel dysfunction; oxaliplatin toxicity; potassium channel dysfunction

Introduction Cold allodynia is often seen in the acute phase of oxaliplatin treatment, but the underlying pathophysiology remains unclear. Methods Patients scheduled for adjuvant oxaliplatin for colorectal cancer were examined with quantitative sensory testing and nerve excitability tests at baselin...