Cold aggravates abnormal excitability of motor axons in oxaliplatin‐treated patients
Introduction Cold allodynia is often seen in the acute phase of oxaliplatin treatment, but the underlying pathophysiology remains unclear. Methods Patients scheduled for adjuvant oxaliplatin for colorectal cancer were examined with quantitative sensory testing and nerve excitability tests at baselin...
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Published in | Muscle & nerve Vol. 61; no. 6; pp. 796 - 800 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken, USA
John Wiley & Sons, Inc
01.06.2020
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Introduction
Cold allodynia is often seen in the acute phase of oxaliplatin treatment, but the underlying pathophysiology remains unclear.
Methods
Patients scheduled for adjuvant oxaliplatin for colorectal cancer were examined with quantitative sensory testing and nerve excitability tests at baseline and after the second or third oxaliplatin cycle at different skin temperatures.
Results
Seven patients were eligible for examination. All patients felt evoked pain and tingling when touching something cold after oxaliplatin infusion. Oxaliplatin decreased motor nerve superexcitability (P < .001), increased relative refractory period (P = .011), and caused neuromyotonia‐like after‐activity. Cooling exacerbated these changes and prolonged the accommodation half‐time.
Discussion
The findings suggest that a combined effect of oxaliplatin and cooling facilitates nerve excitability changes and neuromyotonia‐like after‐activity in peripheral nerve axons. A possible mechanism is the slowing in gating of voltage‐dependent fast sodium and slow potassium channels, which results in symptoms of cold allodynia. |
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Bibliography: | Funding information Aarhus Universitet; Danish National Research Foundation, Grant/Award Number: DNRF121; EU Horizon 2020 research and innovation programme, Grant/Award Number: 633491, DOLORisk Funding information Aarhus Universitet; Danish National Research Foundation, Grant/Award Number: DNRF121; EU Horizon 2020 research and innovation programme, Grant/Award Number: 633491, DOLORisk |
ISSN: | 0148-639X 1097-4598 |
DOI: | 10.1002/mus.26852 |