Line‐field confocal optical coherence tomography for actinic keratosis and squamous cell carcinoma: a descriptive study

• Published in: Clinical and experimental dermatology Vol. 46; no. 8; pp. 1530 - 1541
• Main Authors: Cinotti, E., Tognetti, L., Cartocci, A., Lamberti, A., Gherbassi, S., Orte Cano, C., Lenoir, C., Dejonckheere, G., Diet, G., Fontaine, M., Miyamoto, M., Perez‐Anker, J., Solmi, V., Malvehy, J., Marmol, V., Perrot, J. L., Rubegni, P., Suppa, M.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2021; John Wiley and Sons Inc
• Subjects: Adult; Aged; Aged, 80 and over; Basal cell carcinoma; Carcinoma, Squamous Cell - diagnostic imaging; Carcinoma, Squamous Cell - pathology; Diagnosis, Differential; Female; Humans; Invasiveness; Keratosis; Keratosis, Actinic - diagnostic imaging; Keratosis, Actinic - pathology; Lesions; Male; Middle Aged; Morbidity; Original; Retrospective Studies; Skin cancer; Skin Neoplasms - diagnostic imaging; Skin Neoplasms - pathology; Squamous cell carcinoma; Tomography; Tomography, Optical Coherence - methods; Tumors
• ISSN: 0307-6938; 1365-2230; 1365-2230
• DOI: 10.1111/ced.14801

Summary Background Early and accurate diagnosis of cutaneous squamous cell carcinomas (SCCs) and actinic keratoses (AK) is fundamental to reduce their associated morbidity and to select the correct treatment. Line‐field confocal optical coherence tomography (LC‐OCT) is a new imaging device that can characterize healthy skin and basal cell carcinoma, but no large studies on keratinocyte cell tumours have yet been published. Aim To identify and describe LC‐OCT criteria associated with SCC and AK, and to compare LC‐OCT findings in these tumours. Methods A retrospective observational multicentre study was conducted. Lesions were imaged with the LC‐OCT device before surgery and examined histologically. LC‐OCT criteria for AK/SCC were identified and their presence was evaluated in all study lesions. Univariate and multivariate analyses were performed to compare AK and SCCs, and to investigate differences between in situ and invasive tumours. Results In total, 158 patients with 50 AK and 108 SCCs (62 in situ and 46 invasive) were included. Cytological and architectural alterations were found in most lesions, and differences were found between AK and SCCs. Although the visualization of the dermoepidermal junction (DEJ) was often hampered by hyperkeratosis and acanthosis, an outlined DEJ without broad strands was observed in almost all AK and almost all in situ SCCs, but in only three invasive SCCs (P < 0.001) when the DEJ was detectable. Conclusion Our results suggest that LC‐OCT can help clinicians in the identification of AK and SCC and their differentiation, providing a real‐time and noninvasive examination. Further studies are needed to confirm our data.