The Hippo pathway: Horizons for innovative treatments of peripheral nerve diseases

Initially identified in Drosophila, the Hippo signaling pathway regulates how cells respond to their environment by controlling proliferation, migration and differentiation. Many recent studies have focused on characterizing Hippo pathway function and regulation in mammalian cells. Here, we present...

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Published inJournal of the peripheral nervous system Vol. 26; no. 1; pp. 4 - 16
Main Authors Feltri, M. Laura, Weaver, Michael R., Belin, Sophie, Poitelon, Yannick
Format Journal Article
LanguageEnglish
Published Malden, USA Wiley Periodicals, Inc 01.03.2021
Wiley Subscription Services, Inc
Subjects
Cell proliferation
Genetic disorders
Hippo
Mammalian cells
nerve injury and regeneration
Nervous system
neurofibromatosis
Neurological disorders
Peripheral nerves
peripheral neuropathy
schwann cell
Signal transduction
Tumors
YAP/TAZ
schwann cell
neurofibromatosis
nerve injury and regeneration
YAP/TAZ
peripheral neuropathy
Hippo
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Summary:Initially identified in Drosophila, the Hippo signaling pathway regulates how cells respond to their environment by controlling proliferation, migration and differentiation. Many recent studies have focused on characterizing Hippo pathway function and regulation in mammalian cells. Here, we present a brief overview of the major components of the Hippo pathway, as well as their regulation and function. We comprehensively review the studies that have contributed to our understanding of the Hippo pathway in the function of the peripheral nervous system and in peripheral nerve diseases. Finally, we discuss innovative approaches that aim to modulate Hippo pathway components in diseases of the peripheral nervous system.
Bibliography:Funding information
National Institute of Neurological Disorders and Stroke, Grant/Award Numbers: R01NS110627, R01NS45630
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1085-9489
1529-8027
DOI:10.1111/jns.12431