Treatable inherited rare movement disorders

• Published in: Movement disorders Vol. 33; no. 1; pp. 21 - 35
• Main Authors: Jinnah, H. A., Albanese, Alberto, Bhatia, Kailash P., Cardoso, Francisco, Da Prat, Gustavo, de Koning, Tom J., Espay, Alberto J., Fung, Victor, Garcia‐Ruiz, Pedro J., Gershanik, Oscar, Jankovic, Joseph, Kaji, Ryuji, Kotschet, Katya, Marras, Connie, Miyasaki, Janis M., Morgante, Francesca, Munchau, Alexander, Pal, Pramod Kumar, Rodriguez Oroz, Maria C., Rodríguez‐Violante, Mayela, Schöls, Ludger, Stamelou, Maria, Tijssen, Marina, Uribe Roca, Claudia, de la Cerda, Andres, Gatto, Emilia M.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2018
• Subjects: Clinical trials; Clinical Trials as Topic - methods; Dihydroxyphenylalanine; Dystonia; experimental therapeutics; Humans; inherited disease; Movement disorders; Movement Disorders - genetics; Movement Disorders - therapy; orphan disease; Parkinson's disease; Rare disease; Rare Diseases - genetics; Rare Diseases - therapy; treatment; Treatment Outcome; Wilson's disease; inherited disease; orphan disease; treatment; experimental therapeutics; Rare disease
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.27140

ABSTRACT There are many rare movement disorders, and new ones are described every year. Because they are not well recognized, they often go undiagnosed for long periods of time. However, early diagnosis is becoming increasingly important. Rapid advances in our understanding of the biological mechanisms responsible for many rare disorders have enabled the development of specific treatments for some of them. Well‐known historical examples include Wilson disease and dopa‐responsive dystonia, for which specific and highly effective treatments have life‐altering effects. In recent years, similarly specific and effective treatments have been developed for more than 30 rare inherited movement disorders. These treatments include specific medications, dietary changes, avoidance or management of certain triggers, enzyme replacement therapy, and others. This list of treatable rare movement disorders is likely to grow during the next few years because a number of additional promising treatments are actively being developed or evaluated in clinical trials. © 2017 International Parkinson and Movement Disorder Society