Salivary Proteome and Its Genetic Polymorphisms
: Salivary diagnostics for oral as well as systemic diseases is dependent on the identification of biomolecules reflecting a characteristic change in presence, absence, composition, or structure of saliva components found under healthy conditions. Most of the biomarkers suitable for diagnostics com...
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Published in | Annals of the New York Academy of Sciences Vol. 1098; no. 1; pp. 22 - 50 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Malden, USA
Blackwell Publishing Inc
01.03.2007
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Subjects | |
Online Access | Get full text |
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Summary: | : Salivary diagnostics for oral as well as systemic diseases is dependent on the identification of biomolecules reflecting a characteristic change in presence, absence, composition, or structure of saliva components found under healthy conditions. Most of the biomarkers suitable for diagnostics comprise proteins and peptides. The usefulness of salivary proteins for diagnostics requires the recognition of typical features, which make saliva as a body fluid unique. Salivary secretions reflect a degree of redundancy displayed by extensive polymorphisms forming families for each of the major salivary proteins. The structural differences among these polymorphic isoforms range from distinct to subtle, which may in some cases not even affect the mass of different family members. To facilitate the use of modern state‐of‐the‐art proteomics and the development of nanotechnology‐based analytical approaches in the field of diagnostics, the salient features of the major salivary protein families are reviewed at the molecular level. Knowledge of the structure and function of salivary gland–derived proteins/peptides has a critical impact on the rapid and correct identification of biomarkers, whether they originate from exocrine or non‐exocrine sources. |
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Bibliography: | ArticleID:NYAS30 ark:/67375/WNG-D84XR1ZR-N istex:9FFF91792FF41A7636DB87F4EDF9B44E107729F2 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0077-8923 1749-6632 |
DOI: | 10.1196/annals.1384.030 |