Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Randomization Approach

• Published in: Movement disorders Vol. 36; no. 10; pp. 2264 - 2272
• Main Authors: Kusters, Cynthia D.J., Paul, Kimberly C., Duarte Folle, Aline, Keener, Adrienne M., Bronstein, Jeff M., Bertram, Lars, Hansen, Johnni, Horvath, Steve, Sinsheimer, Janet S., Lill, Christina M., Ritz, Beate R.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.10.2021; Wiley Subscription Services, Inc
• Subjects: Age; Consortia; Female; females; Genetic diversity; Genome-wide association studies; Genome-Wide Association Study; Genomes; Humans; Male; Menarche; Mendelian randomization; Mendelian Randomization Analysis; Menopause; Movement disorders; Neurodegenerative diseases; Neuroprotection; Parkinson Disease - epidemiology; Parkinson Disease - genetics; Parkinson's disease; Polymorphism, Single Nucleotide - genetics; Population studies; Population-based studies; Risk Factors; Sex hormones; Statistical analysis; Womens health; Denmark; Parkinson's disease; Mendelian randomization; menopause; females; menarche

ABSTRACT Background Studies of Parkinson's disease (PD) and the association with age at menarche or menopause have reported inconsistent findings. Mendelian randomization (MR) may address measurement errors because of difficulties accurately reporting the age these life events occur. Objective...