Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits us...

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Published inClinical and translational science Vol. 11; no. 5; pp. 461 - 470
Main Authors Coussens, Nathan P., Sittampalam, G. Sitta, Guha, Rajarshi, Brimacombe, Kyle, Grossman, Abigail, Chung, Thomas D. Y., Weidner, Jeffrey R., Riss, Terry, Trask, O. Joseph, Auld, Douglas, Dahlin, Jayme L., Devanaryan, Viswanath, Foley, Timothy L., McGee, James, Kahl, Steven D., Kales, Stephen C., Arkin, Michelle, Baell, Jonathan, Bejcek, Bruce, Gal‐Edd, Neely, Glicksman, Marcie, Haas, Joseph V., Iversen, Philip W., Hoeppner, Marilu, Lathrop, Stacy, Sayers, Eric, Liu, Hanguan, Trawick, Bart, McVey, Julie, Lemmon, Vance P., Li, Zhuyin, McManus, Owen, Minor, Lisa, Napper, Andrew, Wildey, Mary Jo, Pacifici, Robert, Chin, William W., Xia, Menghang, Xu, Xin, Lal‐Nag, Madhu, Hall, Matthew D., Michael, Sam, Inglese, James, Simeonov, Anton, Austin, Christopher P.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.09.2018
John Wiley and Sons Inc
Subjects
Assaying
Automation
Biological Assay - methods
Biology
Collaboration
Data analysis
Drug development
Drug Discovery
E-books
Geography
High-Throughput Screening Assays
Humans
Hypothesis testing
Laboratories
National libraries
Pharmaceutical industry
Pharmacology
Physiology
R&D
Research & development
Researchers
Scientists
Translational Medical Research
Tutorial
Workshops
Online AccessGet full text

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Abstract The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.
AbstractList The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.
Abstract The Assay Guidance Manual (AGM) is an e Book of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists .
The Assay Guidance Manual (AGM) is an e Book of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists .
Author Brimacombe, Kyle
Baell, Jonathan
Iversen, Philip W.
Simeonov, Anton
Minor, Lisa
Devanaryan, Viswanath
McVey, Julie
Grossman, Abigail
Kahl, Steven D.
Wildey, Mary Jo
Xu, Xin
Austin, Christopher P.
Lemmon, Vance P.
Pacifici, Robert
Weidner, Jeffrey R.
Foley, Timothy L.
Kales, Stephen C.
Hall, Matthew D.
Napper, Andrew
Arkin, Michelle
Xia, Menghang
McGee, James
Coussens, Nathan P.
Lal‐Nag, Madhu
Gal‐Edd, Neely
Chung, Thomas D. Y.
Chin, William W.
Lathrop, Stacy
Bejcek, Bruce
Trask, O. Joseph
Glicksman, Marcie
Dahlin, Jayme L.
Liu, Hanguan
Trawick, Bart
Sittampalam, G. Sitta
McManus, Owen
Guha, Rajarshi
Haas, Joseph V.
Sayers, Eric
Li, Zhuyin
Michael, Sam
Hoeppner, Marilu
Auld, Douglas
Riss, Terry
Inglese, James
AuthorAffiliation 24 Harvard Medical School, Boston Massachusetts United States
12 Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences Monash University Parkville Australia
18 Bristol‐Myers Squibb Lead Discovery and Optimization Princeton New Jersey United States
4 Promega Corporation Madison Wisconsin United States
1 National Center for Advancing Translational Sciences National Institutes of Health Rockville Maryland United States
3 QualSci Consulting LLC Carmel Indiana United States
2 Conrad Prebys Center for Chemical Genomics Sanford Burnham Prebys Medical Discovery Institute La Jolla California United States
8 Charles River Laboratories Souderton Pennsylvania United States
17 Miami Project to Cure Paralysis University of Miami Miller School of Medicine Miami Florida United States
15 Orig3n, Boston Massachusetts United States
20 In Vitro Strategies, LLC Flemington New Jersey United States
22 Merck Research Laboratories Kenilworth New Jersey United States
5 PerkinElmer, Inc., Waltham Massachusetts Un
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/29877628$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2018 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society of Clinical Pharmacology and Therapeutics
2018 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society of Clinical Pharmacology and Therapeutics.
2018. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2018 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society of Clinical Pharmacology and Therapeutics
– notice: 2018 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society of Clinical Pharmacology and Therapeutics.
– notice: 2018. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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2018 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society of Clinical Pharmacology and Therapeutics.
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Notes This article has been contributed to by US Government employees and their work is in the public domain in the USA.
Nathan P. Coussens, G. Sitta Sittampalam, and Rajarshi Guha contributed equally to this work.
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Snippet The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery....
Abstract The Assay Guidance Manual (AGM) is an e Book of best practices for the design, development, and implementation of robust assays for early drug...
The Assay Guidance Manual (AGM) is an e Book of best practices for the design, development, and implementation of robust assays for early drug discovery....
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SubjectTerms Assaying
Automation
Biological Assay - methods
Biology
Collaboration
Data analysis
Drug development
Drug Discovery
E-books
Geography
High-Throughput Screening Assays
Humans
Hypothesis testing
Laboratories
National libraries
Pharmaceutical industry
Pharmacology
Physiology
R&D
Research & development
Researchers
Scientists
Translational Medical Research
Tutorial
Workshops
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Title Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
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