Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits us...

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Published inClinical and translational science Vol. 11; no. 5; pp. 461 - 470
Main Authors Coussens, Nathan P., Sittampalam, G. Sitta, Guha, Rajarshi, Brimacombe, Kyle, Grossman, Abigail, Chung, Thomas D. Y., Weidner, Jeffrey R., Riss, Terry, Trask, O. Joseph, Auld, Douglas, Dahlin, Jayme L., Devanaryan, Viswanath, Foley, Timothy L., McGee, James, Kahl, Steven D., Kales, Stephen C., Arkin, Michelle, Baell, Jonathan, Bejcek, Bruce, Gal‐Edd, Neely, Glicksman, Marcie, Haas, Joseph V., Iversen, Philip W., Hoeppner, Marilu, Lathrop, Stacy, Sayers, Eric, Liu, Hanguan, Trawick, Bart, McVey, Julie, Lemmon, Vance P., Li, Zhuyin, McManus, Owen, Minor, Lisa, Napper, Andrew, Wildey, Mary Jo, Pacifici, Robert, Chin, William W., Xia, Menghang, Xu, Xin, Lal‐Nag, Madhu, Hall, Matthew D., Michael, Sam, Inglese, James, Simeonov, Anton, Austin, Christopher P.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.09.2018
John Wiley and Sons Inc
Subjects
Assaying
Automation
Biological Assay - methods
Biology
Collaboration
Data analysis
Drug development
Drug Discovery
E-books
Geography
High-Throughput Screening Assays
Humans
Hypothesis testing
Laboratories
National libraries
Pharmaceutical industry
Pharmacology
Physiology
R&D
Research & development
Researchers
Scientists
Translational Medical Research
Tutorial
Workshops
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Summary:The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.
Bibliography:This article has been contributed to by US Government employees and their work is in the public domain in the USA.
Nathan P. Coussens, G. Sitta Sittampalam, and Rajarshi Guha contributed equally to this work.
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ISSN:1752-8054
1752-8062
DOI:10.1111/cts.12570