Listeria Cell Wall Fraction: A B Cell Mitogen

A crude cell wall-rich fraction of Listeria monocytogenes contains a substance or substances which cause blast transformation and thymidine incorporation by mouse spleen cells. The substance, Listeria cell wall fraction (LCWF), is a B cell mitogen in the mouse. It is not endotoxin, in that it stimul...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 114; no. 3; pp. 1132 - 1134
Main Authors Cohen, J. John, Rodriguez, Gilberto E, Kind, Phyllis D, Campbell, Priscilla A
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 01.03.1975
Subjects
Animals
B-Lymphocytes - immunology
Cell Wall - immunology
Cells, Cultured
Fluorescent Antibody Technique
Goats - immunology
Immune Sera
Listeria monocytogenes - immunology
Male
Mice
Mice, Inbred BALB C
Mitogens
Rabbits - immunology
Sonication
Species Specificity
Spleen - cytology
Thymidine - metabolism
Tritium
Online AccessGet full text

Cover

More Information
Summary:A crude cell wall-rich fraction of Listeria monocytogenes contains a substance or substances which cause blast transformation and thymidine incorporation by mouse spleen cells. The substance, Listeria cell wall fraction (LCWF), is a B cell mitogen in the mouse. It is not endotoxin, in that it stimulates B cells in C3H/HeJ mice. It is weakly mitogenic for rat spleen cells and not at all mitogenic for human peripheral blood or tonsil lymphocytes. Thus, it is dissimilar to both endotoxin and purified protein derivative (PPD) in its spectrum of activity. A cell wall-associated mitogen may play an early role in Listeria resistance.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.114.3.1132