Cortical Responses to the Amplitude Envelopes of Sounds Change with Age

• Published in: The Journal of neuroscience Vol. 41; no. 23; pp. 5045 - 5055
• Main Authors: Irsik, Vanessa C, Almanaseer, Ala, Johnsrude, Ingrid S, Herrmann, Björn
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 09.06.2021
• Subjects: Acoustics; Adolescent; Adult; Adults; Age; Aged; Aged, 80 and over; Aging; Aging - physiology; Amplitudes; Auditory Cortex - physiology; Auditory Perception - physiology; Cortex (auditory); Decay; Decay rate; EEG; Electroencephalography; Envelopes; Excitability; Female; Humans; Male; Middle Aged; Noise; Older people; Perceptual Masking - physiology; Sine waves; Speech; Speech sounds; Synchronism; Synchronization; Young Adult; hearing; aging; neural synchronization; nonsinusoidal signal shape; envelope tracking
• ISSN: 0270-6474; 1529-2401; 1529-2401
• DOI: 10.1523/JNEUROSCI.2715-20.2021

Many older listeners have difficulty understanding speech in noise, when cues to speech-sound identity are less redundant. The amplitude envelope of speech fluctuates dramatically over time, and features such as the rate of amplitude change at onsets (attack) and offsets (decay), signal critical information about the identity of speech sounds. Aging is also thought to be accompanied by increases in cortical excitability, which may differentially alter sensitivity to envelope dynamics. Here, we recorded electroencephalography in younger and older human adults (of both sexes) to investigate how aging affects neural synchronization to 4 Hz amplitude-modulated noises with different envelope shapes (ramped: slow attack and sharp decay; damped: sharp attack and slow decay). We observed that subcortical responses did not differ between age groups, whereas older compared with younger adults exhibited larger cortical responses to sound onsets, consistent with an increase in auditory cortical excitability. Neural activity in older adults synchronized more strongly to rapid-onset, slow-offset (damped) envelopes, was less sinusoidal, and was more peaked. Younger adults demonstrated the opposite pattern, showing stronger synchronization to slow-onset, rapid-offset (ramped) envelopes, as well as a more sinusoidal neural response shape. The current results suggest that age-related changes in the excitability of auditory cortex alter responses to envelope dynamics. This may be part of the reason why older adults experience difficulty understanding speech in noise. Many middle-aged and older adults report difficulty understanding speech when there is background noise, which can trigger social withdrawal and negative psychosocial health outcomes. The difficulty may be related to age-related changes in how the brain processes temporal sound features. We tested younger and older people on their sensitivity to different envelope shapes, using EEG. Our results demonstrate that aging is associated with heightened sensitivity to sounds with a sharp attack and gradual decay, and sharper neural responses that deviate from the sinusoidal features of the stimulus, perhaps reflecting increased excitability in the aged auditory cortex. Altered responses to temporal sound features may be part of the reason why older adults often experience difficulty understanding speech in social situations.