Enediynes bearing polyfluoroaryl sulfoxide as new antiproliferative agents with dual targeting of microtubules and DNA

• Published in: European journal of medicinal chemistry Vol. 148; pp. 306 - 313
• Main Authors: Borie, Cyril, Mondal, Shovan, Arif, Tanzeel, Briand, Manon, Lingua, Hugo, Dumur, Frédéric, Gigmes, Didier, Stocker, Pierre, Barbarat, Bernadette, Robert, Viviane, Nicoletti, Cendrine, Olive, Daniel, Maresca, Marc, Nechab, Malek
• Format: Journal Article
• Language: English
• Published: ISSY-LES-MOULINEAUX Elsevier Masson SAS 25.03.2018; Elsevier
• Subjects: Anticancer; Antineoplastic Agents - chemistry; Cell Line, Tumor; Chemical Sciences; Chemistry, Medicinal; DNA - drug effects; DNA Breaks, Double-Stranded - drug effects; DNA Breaks, Double-Stranded - radiation effects; DNA cleavage; Enediynes; Enediynes - chemistry; Humans; Life Sciences & Biomedicine; Light activation; Medicinal Chemistry; Microtubules; Microtubules - drug effects; Pharmacology & Pharmacy; Science & Technology; Sulfoxides - chemistry; Ultraviolet Rays; Enediynes; DNA cleavage; Light activation; Anticancer; Microtubules; HYPOXIC TUMORS; PANCREATIC-CANCER; LYSINE; SULFONES; CLEAVAGE; BERGMAN CYCLIZATION; PH-GATED TRANSITIONS; PHOTOCLEAVAGE; IN-VIVO; SELECTIVITY; light activation
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2018.02.030

A novel series of enediynes possessing pentafluorophenylsulfoxide have been developed. The innovative compounds possess antiproliferative activity against a broad panel of human cancer cells originating from breast, blood, lung, kidney, colon, prostate, pancreas or skin with IC50 ranging from 0.6 to 3.4 μM. The antiproliferative activity of enediynes in darkness is associated to their ability to compromise microtubule network. In addition, exposure to UV leads to double-stranded DNA cleavage caused by the newly synthesized molecules reducing further their IC50 in nanomolar range against human tumor cells, including chemo-resistant pancreatic cancer cells. Taken together, the examined data demonstrate that enediynes possessing pentafluorosulfoxide are promising molecules in the cancer therapy. [Display omitted] •Novel Enediynes as a potential antiproliferative drugs.•Dual Targeting of Microtubules and DNA.•IC50 ranging from 0.6 to 3.4 μM against a braod panel of human cancer cells.•Enhanced activity upon photoactivation.•Compound 4i showed double-stranded DNA cleavage.