Endocrine response to acute resistance exercise in obese versus lean physically active men

• Published in: European journal of applied physiology Vol. 115; no. 6; pp. 1359 - 1366
• Main Authors: Rubin, Daniela A., Pham, Hoang N., Adams, Eric S., Tutor, Andrew R., Hackney, Anthony C., Coburn, Jared W., Judelson, Daniel A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2015; Springer Nature B.V
• Subjects: Adult; Biomedical and Life Sciences; Biomedicine; Blood Pressure; Body composition; Body fat; Case-Control Studies; Growth hormones; Health care; Human Growth Hormone - blood; Human Physiology; Humans; Insulin resistance; Insulin-Like Growth Factor I - metabolism; Insulin-like growth factors; Male; Metabolism; Obesity; Obesity - blood; Obesity - physiopathology; Occupational Medicine/Industrial Medicine; Original Article; Resistance Training; Sports Medicine; Strength training; Testosterone; Testosterone - blood; United States > US; Obesity; Testosterone; Growth hormone; Resistance exercise
• ISSN: 1439-6319; 1439-6327
• DOI: 10.1007/s00421-015-3105-0

Purpose Resistance exercise induces a host of endocrine responses that potentiate its effects on body composition and metabolism. Excess adiposity negatively affects some hormonal responses to exercise in sedentary men. This study compared the resistance exercise (RE)-associated growth hormone (GH), insulin-like growth factor-1 (IGF-1), and testosterone responses in lean vs. obese physically active men. Methods Ten healthy physically active obese males (body fat  % 36.2 ± 4.03, age 24.6 ± 3.7 years, mass 104.5 ± 15.5 kg, height 178.8 ± 6.0 cm) were compared to ten lean counterparts (body fat  % 12.7 ± 2.9, age 24.6 ± 3.7 years, mass 77.1 ± 6.4 kg, height 177.2 ± 4.8 cm). The muscular endurance RE protocol consisted of six sets of ten repetitions per leg of stepping onto an elevated platform (20 % of participant’s height) while wearing a weighted-vest (50 % of participant’s lean mass). Pre-, immediately post-exercise (IP), and three more blood samples were collected during the one-hour recovery. Results When accounting for baseline differences there were no group by time interactions for GH ( p  = 0.33); or LH ( p  = 0.52). Lean presented a trend towards significance for higher IGF-1 IP ( p  = 0.08) than obese. Testosterone IP was similar in obese and lean, but lower in obese than lean at 30 min into recovery ( p  < 0.01). AUC were lower in obese than lean for all hormones ( p  < 0.05 for all). Conclusion These findings suggest that excess adiposity does not appear to negatively affect the immediate GH and T responses to RE in active males; but possibly negatively affects IGF-1. However, the baseline and integrated concentrations during recovery appear negatively affected by excess adiposity.