The Clinical Utility of Serum CXCR-2 Assessment in Colorectal Cancer (CRC) Patients

• Published in: Anticancer research Vol. 41; no. 3; pp. 1421 - 1428
• Main Authors: PĄCZEK, SARA, ŁUKASZEWICZ-ZAJĄC, MARTA, GRYKO, MARIUSZ, KULCZYŃSKA-PRZYBIK, AGNIESZKA, MROCZKO, BARBARA
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.03.2021
• Subjects: Angiogenesis; Biomarkers; Biomarkers, Tumor - blood; C-reactive protein; C-Reactive Protein - analysis; Cancer; Carcinoembryonic antigen; Carcinoembryonic Antigen - blood; Chemiluminescence; Chemokine receptors; Chemokines; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - blood; Colorectal Neoplasms - diagnosis; CXCR2 protein; Diagnosis; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoassay; Ligands; Lymphatic system; Male; Metastasis; Microparticles; Neutrophils; Prognosis; Proteins; Receptors, Interleukin-8B - blood; Regression analysis; ROC Curve; Serum levels; Statistical analysis; Tumor markers; Tumors; Poland; United States > US; colorectal cancer; CXCR-2; Chemokines; chemokine receptor
• ISSN: 0250-7005; 1791-7530; 1791-7530
• DOI: 10.21873/anticanres.14899

The current study aimed to evaluate the clinical utility of the levels of the C-X-C-motif chemokine receptor-2 (CXCR-2) serum receptor in comparison to the carcinoembryonic antigen (CEA) tumor marker and - the C-reactive protein (CRP) inflammatory marker in the diagnosis and prognosis of colorectal cancer (CRC). Our study comprised 59 patients with CRC and 46 healthy subjects. Serum concentrations of the analyzed proteins were measured using enzyme-linked immunosorbent assay, chemiluminescent microparticle immunoassay and immunoturbidimetric methods. Serum levels of CXCR-2 were lower, while those of CEA and CRP were significantly higher in CRC patients in comparison to the control group. The diagnostic sensitivity of CXCR-2 was higher than that of CEA, and increased when CXCR-2 analysis was combined with CEA or CRP. According to our knowledge, this is the first study concerning the significance of CXCR2 as a CRC biomarker. Measurement of the serum levels of CXCR-2 may improve the diagnosis efficiency of CRC patients, especially in combination with the tumor marker CEA.