Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. The pathogenetic origin of vitiligo revolves around autoimmune destruction of melanocytes in which, for instance, oxidative stress is responsible for melanocyte molecular, organelle dysfunction and melanocy...

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Published inFrontiers in pharmacology Vol. 12; p. 685116
Main Authors Pang, Yaobin, Wu, Shi, He, Yingjie, Nian, Qing, Lei, Jing, Yao, Yejing, Guo, Jing, Zeng, Jinhao
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 11.11.2021
Subjects
flavonoids
melanocytes
natural product
oxidative stress
Pharmacology
phenols
vitiligo
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Summary:Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. The pathogenetic origin of vitiligo revolves around autoimmune destruction of melanocytes in which, for instance, oxidative stress is responsible for melanocyte molecular, organelle dysfunction and melanocyte specific antigen exposure as well as melanocyte cell death and thus serves as an important contributor for vitiligo progression. In recent years, natural products have shown a wide range of pharmacological bioactivities against many skin diseases, and this review focuses on the effects and mechanisms of natural compounds against vitiligo models. It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/β-catenin signaling pathways were reported to be implicated in these protective effects. This review discusses the great potential of plant derived natural products as anti-vitiligo agents, as well as the future directions to explore.
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This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology
Reviewed by: Vuyisile Samuel Thibane, University of South Africa, South Africa
Erna Karalija, University of Sarajevo, Bosnia and Herzegovina
Edited by: Gokhan Zengin, Selcuk University, Turkey
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.685116