Opioids in Cancer Development, Progression and Metastasis: Focus on Colorectal Cancer

Opinion statement So far, opioids have been successfully used to reduce cancer pain in patients in order to improve their quality of life. However, the use of opioids leads to numerous side effects such as constipation, drowsiness, nausea, itching, increased sweating and hormonal changes. In this re...

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Bibliographic Details
Published inCurrent treatment options in oncology Vol. 21; no. 1; p. 6
Main Authors Szczepaniak, Adrian, Fichna, Jakub, Zielińska, Marta
Format Journal Article
LanguageEnglish
Published New York Springer US 2020
Subjects
Lower Gastrointestinal Cancers (AB Benson
Lower Gastrointestinal Cancers (AB Benson, Section Editor)
Medicine
Medicine & Public Health
Oncology
Section Editor
Topical Collection on Lower Gastrointestinal Cancers
Opioid receptors
Endogenous opioid system
Opium
Colorectal cancer
Opioids
Cancer
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Summary:Opinion statement So far, opioids have been successfully used to reduce cancer pain in patients in order to improve their quality of life. However, the use of opioids leads to numerous side effects such as constipation, drowsiness, nausea, itching, increased sweating and hormonal changes. In this review, we described the action of opioids in several molecular pathways significant for maintenance of the intestinal homeostasis including the impact on the intestinal epithelium integrity, changes in microbiome composition, modulation of the immune system or induction of apoptosis and inhibition of angiogenesis. We summed up the role of individual opioids in the processes involved in the growth and development of cancer and elucidated if targeting opioid receptors may constitute novel therapeutic option in colon cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1527-2729
1534-6277
DOI:10.1007/s11864-019-0699-1