Serological responses following influenza A H1N1 2009 infection in adults

• Published in: The Journal of infection Vol. 62; no. 5; pp. 388 - 393
• Main Authors: Tan, Sophia, Gordon, David L, Honda-Okubo, Yoshikazu, Petrovsky, Nikolai, Phillips, Peter, Huddleston, Sandra, Sadlon, Tania A
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2011
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody response; Cross Reactions; Cross reactive antibody; Female; Haemagglutination inhibition; Hemagglutination Inhibition Tests; Humans; Infectious Disease; Influenza A; Influenza A Virus, H1N1 Subtype - immunology; Influenza A Virus, H3N2 Subtype - immunology; Influenza, Human - immunology; Influenza, Human - virology; Male; Middle Aged; Pregnancy; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - virology; Young Adult; Haemagglutination inhibition; Influenza A; Cross reactive antibody; Antibody response
• ISSN: 0163-4453; 1532-2742
• DOI: 10.1016/j.jinf.2011.03.002

Summary Objective The aim of this study was to determine the humoral immune response to influenza A H1N1 2009 and cross reactivity against seasonal H1N1 and H3N2 strains. Methods Baseline and convalescent sera from 88 subjects with confirmed H1N1 2009 were screened for serological responses by HAI assay. Results Protective antibody titres to H1N1 2009 were present in 87% post-infection, but varied with age, sex and pregnancy. Some cross reactivity with seasonal influenza strains was observed. Conclusions Females and pregnant subjects had an attenuated immune response to H1N1 2009 in comparison to the rest of the study population. Antibodies from the serum of H1N1 2009 infected subjects cross reacted with seasonal H1N1 and H3N2 influenza viruses.