Vitamin D and systemic lupus erythematosus: state of the art

• Published in: Clinical rheumatology Vol. 33; no. 8; pp. 1033 - 1038
• Main Authors: Schneider, Laiana, dos Santos, Amanda Senna Pereira, Santos, Marcele, da Silva Chakr, Rafael Mendonça, Monticielo, Odirlei Andre
• Format: Journal Article
• Language: English
• Published: London Springer London 01.08.2014; Springer Nature B.V
• Subjects: Humans; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - drug therapy; Medicine; Medicine & Public Health; Review Article; Rheumatology; Vitamin D - blood; Vitamin D - therapeutic use; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; Vitamin D Deficiency - drug therapy; Systemic lupus erythematosus; 25-Hydroxyvitamin D deficiency; Supplementation; Vitamin D
• ISSN: 0770-3198; 1434-9949
• DOI: 10.1007/s10067-014-2530-5

Systemic lupus erythematosus (SLE) is a systemic inflammatory disease associated with genetic, environmental, hormonal, and immunological factors. One of these factors is vitamin D deficiency. Vitamin D plays many roles in the immune system. Several studies have suggested a potential role in the development of autoimmune diseases. SLE patients have low serum levels of vitamin D, which increase the possibility of an association between vitamin deficiency and disease onset and evolution. This review of the literature presents an analysis of the aspects related to the immunoregulatory effects of vitamin D and its importance for SLE, as well as the recommendations for vitamin D supplementation in these patients.