Taking a bite: proteasomal protein processing

• Published in: Nature cell biology Vol. 4; no. 5; pp. E113 - E116
• Main Authors: Rape, Michael, Jentsch, Stefan
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.05.2002
• Subjects: Animals; Cellular proteins; Cysteine Endopeptidases - metabolism; DNA binding proteins; Genetic aspects; Health aspects; Models, Biological; Multienzyme Complexes - metabolism; NF-kappa B - metabolism; Peptides; Physiological aspects; Polypeptides; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Proteins; Transcription factors; Transcription Factors - metabolism; Ubiquitin - metabolism; Ubiquitin-proteasome system; Yeast; Germany

The proteasome is a hollow cylindrical protease that contains active sites concealed within its central cavity. Proteasomes usually completely degrade substrates into small peptides, but in a few cases, degradation can yield biologically active protein fragments. Examples of this are the transcripti...