Taking a bite: proteasomal protein processing

The proteasome is a hollow cylindrical protease that contains active sites concealed within its central cavity. Proteasomes usually completely degrade substrates into small peptides, but in a few cases, degradation can yield biologically active protein fragments. Examples of this are the transcripti...

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Bibliographic Details
Published inNature cell biology Vol. 4; no. 5; pp. E113 - E116
Main Authors Rape, Michael, Jentsch, Stefan
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.05.2002
Subjects
Animals
Cellular proteins
Cysteine Endopeptidases - metabolism
DNA binding proteins
Genetic aspects
Health aspects
Models, Biological
Multienzyme Complexes - metabolism
NF-kappa B - metabolism
Peptides
Physiological aspects
Polypeptides
Proteasome Endopeptidase Complex
Protein Structure, Tertiary
Proteins
Transcription factors
Transcription Factors - metabolism
Ubiquitin - metabolism
Ubiquitin-proteasome system
Yeast
Germany
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Summary:The proteasome is a hollow cylindrical protease that contains active sites concealed within its central cavity. Proteasomes usually completely degrade substrates into small peptides, but in a few cases, degradation can yield biologically active protein fragments. Examples of this are the transcription factors NF-kappa B, Spt23p and Mga2p, which are generated from precursors by proteasomal processing. How distinct protein domains are spared from degradation remains a matter of debate. Here, we discuss several models and suggest a novel mechanism for proteasomal processing.
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ISSN:1465-7392
1476-4679
DOI:10.1038/ncb0502-e113