Selective laser sintering manufacturing of polycaprolactone bone scaffolds for applications in bone tissue engineering

Purpose – The purpose of this study is to show how selective laser sintering (SLS) manufacturing of bioresorbable scaffolds is used for applications in bone tissue engineering. Design/methodology/approach – Polycaprolactone (PCL) scaffolds were computationally designed and then fabricated via SLS fo...

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Bibliographic Details
Published inRapid prototyping journal Vol. 21; no. 4; pp. 386 - 392
Main Authors Mazzoli, Alida, Ferretti, C, Gigante, A, Salvolini, E, Mattioli-Belmonte, M
Format Journal Article
LanguageEnglish
Published Bradford Emerald Group Publishing Limited 01.01.2015
Subjects
Atoms & subatomic particles
Biocompatibility
Biomedical materials
Bones
Cartilage
Cell adhesion & migration
Data acquisition
Engineering
Exports
Industrial engineering, design & manufacturing
Laser sintering
Manufacturing
Morphology
Particle size
Polycaprolactone
Pore size
Rapid prototyping
Repair
Scaffolds
Selective laser sintering
Software
Stem cells
Tissue engineering
United Kingdom > UK
United States > US
Scotland
Scaffolds
Selective laser sintering
Biological analysis and testing
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Summary:Purpose – The purpose of this study is to show how selective laser sintering (SLS) manufacturing of bioresorbable scaffolds is used for applications in bone tissue engineering. Design/methodology/approach – Polycaprolactone (PCL) scaffolds were computationally designed and then fabricated via SLS for applications in bone and cartilage repair. Findings – Preliminary biocompatibility data were acquired using human mesenchymal stem cells (hMSCs) assuring a satisfactory scaffold colonization by hMSCs. Originality/value – A promising procedure for producing porous scaffolds for the repair of skeletal defects, in tissue engineering applications, was developed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1355-2546
1758-7670
DOI:10.1108/RPJ-04-2013-0040