Low-normal doses of methiopropamine induce aggressive behaviour in mice

Recreational use of illicit methiopropamine (MPA) is a public health concern because it produces neurochemical effects comparable with those induced by methamphetamine (METH). The present study investigated the effects of MPA on the expression of an aggressive behaviour. Eighty CD-1 male mice, after...

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Bibliographic Details
Published inPsychopharmacology Vol. 238; no. 7; pp. 1847 - 1856
Main Authors Foti, Federica, Bilel, Sabrine, Tirri, Micaela, Arfè, Raffaella, Boccuto, Federica, Bernardi, Tatiana, Serpelloni, Giovanni, De-Giorgio, Fabio, Marti, Matteo
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2021
Springer
Springer Nature B.V
Subjects
Aggressive behavior
Aggressiveness
Aggressiveness (Psychology)
Amphetamines
Analysis
Animals
Biomedical and Life Sciences
Biomedicine
Dosage
Dosage and administration
Drug dosages
Human acts
Human behavior
Ischemia
Legal medicine
Locomotor activity
Medicine
Methamphetamine
Methods
Neurosciences
Original Investigation
Pharmacology/Toxicology
Physiological aspects
Psychiatry
Psychopharmacology
Public health
Thiophene
Violence
United States
Italy
Grey zone
New psychoactive substances
Aggressive behaviour
Violence
Methiopropamine
Methamphetamine
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Summary:Recreational use of illicit methiopropamine (MPA) is a public health concern because it produces neurochemical effects comparable with those induced by methamphetamine (METH). The present study investigated the effects of MPA on the expression of an aggressive behaviour. Eighty CD-1 male mice, after receiving intraperitoneal injection of saline, MPA (0.01–10 mg/kg), METH (0.01–10 mg/kg), or AMPH (0.01–10 mg/kg), once a week over a 5-week period, underwent the resident–intruder test and spontaneous locomotor activity measurement. Results showed that all psychostimulants induce aggressive behaviour even at low doses, with a dose-dependent increase and a time-dependent sensitisation. MPA potency was similar to METH and superior to AMPH. Therefore, MPA-induced aggressive behaviour may appear even at MPA dosages free of cardiovascular or other behavioural adverse effects and could become a non-intentional side effect that users experience after increasing and repeating MPA consumption.
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ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-021-05813-y