Applications of Thiol-Ene Chemistry for Peptide Science
Radical thiol-ene chemistry has been demonstrated for a range of applications in peptide science, including macrocyclization, glycosylation and lipidation amongst a myriad of others. The thiol-ene reaction offers a number of advantages in this area, primarily those characteristic of "click"...
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Published in | Frontiers in chemistry Vol. 8; p. 583272 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
12.11.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Radical thiol-ene chemistry has been demonstrated for a range of applications in peptide science, including macrocyclization, glycosylation and lipidation amongst a myriad of others. The thiol-ene reaction offers a number of advantages in this area, primarily those characteristic of "click" reactions. This provides a chemical approach to peptide modification that is compatible with aqueous conditions with high orthogonality and functional group tolerance. Additionally, the use of a chemical approach for peptide modification affords homogeneous peptides, compared to heterogeneous mixtures often obtained through biological methods. In addition to peptide modification, thiol-ene chemistry has been applied in novel approaches to biological studies through synthesis of mimetics and use in development of probes. This review will cover the range of applications of the radical-mediated thiol-ene reaction in peptide and protein science. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 This article was submitted to Organic Chemistry, a section of the journal Frontiers in Chemistry Edited by: Chun Xu, The University of Queensland, Australia Reviewed by: Junfeng Zhao, Jiangxi Normal University, China; Mustafa O. Guler, University of Chicago, United States |
ISSN: | 2296-2646 2296-2646 |
DOI: | 10.3389/fchem.2020.583272 |