Numerical chromosomal aberrations in muscle invasive squamous cell and transitional cell cancer of the urinary bladder: an alternative to classic prognostic indicators?

• Published in: Urology (Ridgewood, N.J.) Vol. 53; no. 5; pp. 1005 - 1010
• Main Authors: Pycha, Armin, Mian, Christine, Posch, Bernd, Haitel, Andrea, Mokhtar, Alaa A, El-Baz, Mahmoud, Ghoneim, Mohamed A, Marberger, Michael
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1999; Elsevier Science
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Transitional Cell - genetics; Carcinoma, Transitional Cell - mortality; Carcinoma, Transitional Cell - pathology; Chromosome Aberrations - genetics; Female; Humans; Male; Medical sciences; Middle Aged; Neoplasm Invasiveness; Nephrology. Urinary tract diseases; Prognosis; Retrospective Studies; Survival Rate; Tumors of the urinary system; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - mortality; Urinary Bladder Neoplasms - pathology; Urinary tract. Prostate gland; Chromosomal aberration; Human; Squamous cell carcinoma; Correlation; Urinary system disease; Prognosis; Space occupying lesion; Smooth muscle; Urinary tract disease; Transitional cell carcinoma; Malignant tumor; Genetic determinism; Urinary bladder; Classification; Bladder disease; Diagnosis; Quantitative analysis
• ISSN: 0090-4295; 1527-9995
• DOI: 10.1016/S0090-4295(98)00626-8

Objectives. To evaluate the prognostic value of chromosomal aberrations in muscle invasive bladder cancer, because they are of diagnostic and prognostic significance in superficial bladder cancer. Methods. One hundred ninety patients, who underwent radical cystectomy because of squamous cell carcinoma (SCC) of the urinary bladder in 94 cases and transitional cell carcinoma (TCC) in 96 cases, were studied retrospectively. Numerical aberrations of chromosomes 7, 9, and 17, p53 positivity, histologic stage and grade, histologic tumor type, lymph node status, and the presence of bilharzial eggs were investigated as possible prognostic factors. Results. Univariate analysis demonstrated the prognostic significance of all parameters analyzed, excluding chromosome 9. Multivariate analysis revealed only T category (P = 0.01095266), lymph node involvement (P = 0.00054877), and p53 positivity (P = 0.0316974) to be independent prognostic factors in muscle invasive SCC and TCC. Conclusions. Although chromosomal aberrations are associated with progression-free survival, they are not independent prognostic factors and give the clinician no additional information on patients with muscle invasive bladder cancer.