New Procedure to Maintain Fecal Microbiota in a Dry Matrix Ready to Encapsulate

Fecal microbiota transplantation (FMT) is one of the recommended treatments for recurrent Clostridioides difficile infection, but endoscopy and available oral formulations still have several limitations in their preparation, storage, and administration. The need for a viable oral formulation that fa...

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Published inFrontiers in cellular and infection microbiology Vol. 12; p. 899257
Main Authors Aira, Andrea, Rubio, Elisa, Ruiz, Andrea, Vergara, Andrea, Casals-Pascual, Climent, Rico, Verónica, Suñé-Negre, Josep Maria, Soriano, Alex
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 10.06.2022
Subjects
adsorbate
capsules
Cellular and Infection Microbiology
FMT
gut microbiota
lyophilization
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Summary:Fecal microbiota transplantation (FMT) is one of the recommended treatments for recurrent Clostridioides difficile infection, but endoscopy and available oral formulations still have several limitations in their preparation, storage, and administration. The need for a viable oral formulation that facilitates the implementation of this highly effective therapy in different settings has led us to test the microcrystalline cellulose particles as an adsorbent of concentrated filtered fresh feces in comparison to lyophilized feces. This free-flowing material can provide protection to bacteria and results in a dried product able to maintain the viability of the microbiota for a long time. Adsorbate formulation showed a stabilizing effect in gut microbiota, maintaining bacteria viability and preserving its diversity, and is a competitive option for lyophilized capsules.
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Reviewed by: Benoit Guery, Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland; Almagul Kushugulova, Nazarbayev University, Kazakhstan
Edited by: Xian-Zheng Zhang, Wuhan University, China
This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.899257