The value of hypercalciuria in patients with osteopenia versus osteoporosis

• Published in: Urolithiasis Vol. 45; no. 3; pp. 279 - 283
• Main Authors: Girón-Prieto, María Sierra, del Carmen Cano-García, María, Poyatos-Andújar, Antonio, Arias-Santiago, Salvador, de Haro-Muñoz, Tomás, Arrabal-Martín, Miguel, Arrabal-Polo, Miguel Ángel
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2017; Springer Nature B.V
• Subjects: Adult; Aged; Bone and Bones - metabolism; Bone Diseases, Metabolic - blood; Bone Diseases, Metabolic - therapy; Bone Diseases, Metabolic - urine; Calcium - urine; Creatinine - blood; Creatinine - urine; Cross-Sectional Studies; Densitometry; Female; Humans; Hypercalciuria - blood; Hypercalciuria - urine; Kidney stones; Male; Medical Biochemistry; Medicine; Medicine & Public Health; Metabolism; Middle Aged; Nephrology; Original Paper; Osteocalcin - blood; Osteocalcin - urine; Osteoporosis; Osteoporosis - blood; Osteoporosis - therapy; Osteoporosis - urine; Urine; Urology; Osteoporosis; Calciuria; Bone markers; Osteopenia
• ISSN: 2194-7228; 2194-7236
• DOI: 10.1007/s00240-016-0909-2

The aim of this study was to analyze the presence of lithogenic metabolic factors in the blood and urine of patients with osteopenia versus osteoporosis. This is a cross-sectional study including 67 patients who were divided into two groups according to the presence of either osteopenia or osteoporosis as measured by bone densitometry: group 1—40 patients with osteopenia (22 men and 18 women) and group 2—27 patients with osteoporosis (13 men and 14 women). Metabolic studies were performed on the blood and urine; statistical analysis was performed comparing means and conducting linear correlation and multivariate analyses with SPSS. Statistical significance was considered to be p  ≤ 0.05. The mean age of patients in group 1 was 52.9 ± 12.8 years versus 50.3 ± 11.4 in group 2; the difference was not statistically significant. In group 2, higher levels of osteocalcin, β-crosslaps, urinary calcium, fasting urine calcium/creatinine, 24 h urine calcium/creatinine and 24 h oxaluria were observed compared to group 1. In the multivariate analysis, only the β-crosslaps and urinary calcium were independently associated with osteoporosis. It would be advisable to determine the urinary calcium levels in patients with osteoporosis since altered levels may necessitate modifying the diagnostic and therapeutic approach to osteoporosis.