Comprehensive analysis of 7-methylguanosine and immune microenvironment characteristics in clear cell renal cell carcinomas

Clear cell renal cell carcinoma (ccRCC) is one of the most common tumors in the urinary system. ccRCC has obvious immunological characteristics, and the infiltration of immune cells is related to the prognosis of ccRCC. The effect of immune checkpoint therapy is related to the dynamic changes of the...

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Published inFrontiers in genetics Vol. 13; p. 866819
Main Authors Xiao, Yu, Yang, Junfeng, Yang, Maolin, Len, Jinjun, Yu, Yanhong
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 08.08.2022
Subjects
clear cell renal cell carcinomas
Genetics
immune checkpoints
immunotherapy
m7G
tumor immune microenvironment
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Summary:Clear cell renal cell carcinoma (ccRCC) is one of the most common tumors in the urinary system. ccRCC has obvious immunological characteristics, and the infiltration of immune cells is related to the prognosis of ccRCC. The effect of immune checkpoint therapy is related to the dynamic changes of the tumor immune microenvironment (TIM). The 7-methylguanosine (m7G) is an additional mRNA modification ability besides m6A, which is closely related to the TIM and affects the occurrence and development of tumors. At present, the correlations between m7G and the immune microenvironment, treatment, and prognosis of ccRCC are not clear. As far as we know, there was no study on the relationship between m7G and the immune microenvironment and survival of clear cell renal cell carcinomas. A comprehensive analysis of the correlations between them and the construction of a prognosis model are helpful to improve the treatment strategy. Two different molecular subtypes were identified in 539 ccRCC samples by describing the differences of 29 m7G-related genes. It was found that the clinical features, TIM, and prognosis of ccRCC patients were correlated with the m7G-related genes. We found that there were significant differences in the expression of PD-1, CTLA4, and PD-L1 between high- and low-risk groups. To sum up, m7G-related genes play a potential role in the TIM, treatment, and prognosis of ccRCC. Our results provide new findings for ccRCC and help to improve the immunotherapy strategies and prognosis of patients.
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Edited by: Nguyen Quoc Khanh Le, Taipei Medical University, Taiwan
This article was submitted to Computational Genomics, a section of the journal Frontiers in Genetics
Reviewed by: Ram Vinay Pandey, Karolinska University Hospital, Sweden
Ning Zhang, Shanghai Jiao Tong University, China
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2022.866819