Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men
Introduction: The characterization of immune and oxidative stress responses to acute and chronic exercise training is important because it may aid in the safety and dose–response prescription of resistance training (RT) in many populations. Purpose: The present study compared changes in acute oxidat...
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Published in | Frontiers in physiology Vol. 12; p. 720773 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
09.09.2021
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Subjects | |
Online Access | Get full text |
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Summary: | Introduction:
The characterization of immune and oxidative stress responses to acute and chronic exercise training is important because it may aid in the safety and dose–response prescription of resistance training (RT) in many populations.
Purpose:
The present study compared changes in acute oxidative stress and markers of apoptosis in immune cells before and after 8 weeks of low-load RT with total or partial blood flow restriction (BFR) versus high-load traditional RT.
Methods:
Twenty-seven untrained men were randomly divided into three groups: traditional RT [75% one-repetition maximum (1-RM)], RT with partial (20% 1-RM), and total BFR (20% 1-RM). Over an 8-week period, participants performed six sets of arm curls until failure with 90 seconds of recovery for 3 days/week. Blood samples were obtained before and after the first and last training sessions.
Results:
Data indicated that all training groups showed similar increases in muscular strength (
p
< 0.001), reduction in mitochondrial membrane potential (MMP) after exercise in neutrophils (
p
< 0.001), and increase in caspase-3 activity after exercise (
p
< 0.001). Traditional RT and total BFR showed increased plasma lipid peroxidation (
p
< 0.001) and protein carbonyls (
p
< 0.001) and lower levels of reduced glutathione (GSH) (
p
< 0.001) after exercise. No change was observed in oxidative stress biomarkers in response to partial BFR (
p
> 0.05).
Conclusion:
Data show that RT with partial BFR can increase muscular strength but still does not augment biomarkers of oxidative stress in untrained men. In addition, RT with total BFR promoted similar responses of oxidative stress and markers of immune cell apoptosis versus traditional RT. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Martin Burtscher, University of Innsbruck, Austria This article was submitted to Exercise Physiology, a section of the journal Frontiers in Physiology ORCID: Douglas Popp Marin, orcid.org/0000-0001-6380-8937; Todd Anthony Astorino, orcid.org/0000-0003-0492-0173; Jonato Prestes, orcid.org/0000-0003-0399-8817; Marcelo Luis Marquezi, orcid.org/0000-0002-6593-941X; Rosemari Otton, orcid.org/0000-0001-5503-3967 These authors have contributed equally to this work Reviewed by: Omar Boukhris, University of Sfax, Tunisia; Tibor Hortobagyi, University Medical Center Groningen, Netherlands |
ISSN: | 1664-042X 1664-042X |
DOI: | 10.3389/fphys.2021.720773 |