The Roles of the Gut Microbiota and Chronic Low-Grade Inflammation in Older Adults With Frailty
Frailty is a major public issue that affects the physical health and quality of life of older adults, especially as the population ages. Chronic low-grade inflammation has been speculated to accelerate the aging process as well as the development of age-related diseases such as frailty. Intestinal h...
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Published in | Frontiers in cellular and infection microbiology Vol. 11; p. 675414 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
01.07.2021
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Subjects | |
Online Access | Get full text |
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Summary: | Frailty is a major public issue that affects the physical health and quality of life of older adults, especially as the population ages. Chronic low-grade inflammation has been speculated to accelerate the aging process as well as the development of age-related diseases such as frailty. Intestinal homeostasis plays a crucial role in healthy aging. The interaction between the microbiome and the host regulates the inflammatory response. Emerging evidence indicates that in older adults with frailty, the diversity and composition structure of gut microbiota are altered. Age-associated changes in gut microbiota composition and in their metabolites contribute to increased gut permeability and imbalances in immune function. In this review, we aim to: identify gut microbiota changes in the aging and frail populations; summarize the role of chronic low-grade inflammation in the development of frailty; and outline how gut microbiota may be related to the pathogenesis of frailty, more specifically, in the regulation of gut-derived chronic inflammation. Although additional research is needed, the regulation of gut microbiota may represent a safe, easy, and inexpensive intervention to counteract the chronic inflammation leading to frailty. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Francesca Romana Ponziani, Internal Medicine, Gastroenterology, Hepatology Fondazione Policlinico Universitario Agostino Gemelli (IRCCS), Italy This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology Reviewed by: Yiorgos Apidianakis, University of Cyprus, Cyprus; Simone Garcovich, Catholic University of the Sacred Heart, Italy |
ISSN: | 2235-2988 2235-2988 |
DOI: | 10.3389/fcimb.2021.675414 |