N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications

N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be installed by the methyltransferase complex and removed by demethylases, which are involved in regulating post-transcriptional expression of target genes. RNA methylation is linked to various inflammatory states, in...

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Published inFrontiers in cell and developmental biology Vol. 9; p. 670711
Main Authors Luo, Jiahui, Xu, Tao, Sun, Kai
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 04.06.2021
Subjects
Cell and Developmental Biology
epigenetics
inflammation
inflammatory disease
N6-methyladenosine
RNA modification
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Summary:N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be installed by the methyltransferase complex and removed by demethylases, which are involved in regulating post-transcriptional expression of target genes. RNA methylation is linked to various inflammatory states, including autoimmunity, infection, metabolic disease, cancer, neurodegenerative diseases, heart diseases, and bone diseases. However, systematic knowledge of the relationship between m6A modification and inflammation in human diseases remains unclear. In this review, we will discuss the association between m6A modification and inflammatory response in diseases, especially the role, mechanisms, and potential clinical application of m6A as a biomarker and therapeutic target for inflammatory diseases.
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Reviewed by: Gioacchino Paolo Marceca, University of Catania, Italy; Abhijit Shukla, Memorial Sloan Kettering Cancer Center, United States; Natalia Pinello, Centenary Institute of Cancer Medicine and Cell Biology, Australia
Edited by: Giovanni Nigita, The Ohio State University, United States
This article was submitted to Epigenomics and Epigenetics, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.670711