Influenza A, Influenza B, and SARS-CoV-2 Similarities and Differences – A Focus on Diagnosis
In late December 2019, the first cases of viral pneumonia caused by an unidentified pathogen were reported in China. Two years later, SARS-CoV-2 was responsible for almost 450 million cases, claiming more than 6 million lives. The COVID-19 pandemic strained the limits of healthcare systems all acros...
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Published in | Frontiers in microbiology Vol. 13; p. 908525 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
20.06.2022
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Subjects | |
Online Access | Get full text |
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Summary: | In late December 2019, the first cases of viral pneumonia caused by an unidentified pathogen were reported in China. Two years later, SARS-CoV-2 was responsible for almost 450 million cases, claiming more than 6 million lives. The COVID-19 pandemic strained the limits of healthcare systems all across the world. Identifying viral RNA through real-time reverse transcription-polymerase chain reaction remains the gold standard in diagnosing SARS-CoV-2 infection. However, equipment cost, availability, and the need for trained personnel limited testing capacity. Through an unprecedented research effort, new diagnostic techniques such as rapid diagnostic testing, isothermal amplification techniques, and next-generation sequencing were developed, enabling accurate and accessible diagnosis. Influenza viruses are responsible for seasonal outbreaks infecting up to a quarter of the human population worldwide. Influenza and SARS-CoV-2 present with flu-like symptoms, making the differential diagnosis challenging solely on clinical presentation. Healthcare systems are likely to be faced with overlapping SARS-CoV-2 and Influenza outbreaks. This review aims to present the similarities and differences of both infections while focusing on the diagnosis. We discuss the clinical presentation of Influenza and SARS-CoV-2 and techniques available for diagnosis. Furthermore, we summarize available data regarding the multiplex diagnostic assay of both viral infections. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 This article was submitted to Infectious Agents and Disease, a section of the journal Frontiers in Microbiology Reviewed by: Hin Fung Tsang, Hong Kong Adventist Hospital, Hong Kong SAR, China; Silvia Spoto, Policlinico Universitario Campus Bio-Medico, Italy; Israel Parra-Ortega, Federico Gómez Children’s Hospital, Mexico; Lalit Batra, University of Louisville, United States Edited by: Bing Gu, Guangdong Provincial People’s Hospital, China |
ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2022.908525 |