A multi-center study on the association between serum magnesium levels and allostatic load in hemodialysis patients

• Published in: Frontiers in physiology Vol. 13; p. 963914
• Main Authors: Zhang, Yingxin, Yang, Zhengling, Yang, Huan, Li, Xiuyong, Liu, Zhi, Bai, Youwei, Qian, Guangrong, Wu, Han, Li, Ji, Guo, Yuwen, Yang, Shanfei, Chen, Lei, Yang, Jian, Han, Jiuhuai, Ma, Shengyin, Yang, Jing, Yu, Linfei, Shui, Runzhi, Jin, Xiping, Wang, Hongyu, Zhang, Fan, Chen, Tianhao, Li, Xinke, Zong, Xiaoying, Liu, Li, Fan, Jihui, Wang, Wei, Zhang, Yong, Shi, Guangcai, Wang, Deguang, Tao, Shuman
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 03.10.2022
• Subjects: allostatic load; clinical; hemodialysis; magnesium; Physiology; stress
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2022.963914

Objective: Serum magnesium (Mg 2+ ) levels are associated with insulin resistance, hypertension, lipid abnormalities, and inflammation. However, limited studies have indicated the relationship between Mg 2+ and multiple system indexes. The purpose of this study was to investigate the association between Mg 2+ and allostatic load (AL) in hemodialysis patients. Methods: A cross-sectional survey was conducted on hemodialysis patients from different centers in Anhui Province, China, between January and December 2020. A total of 3,025 hemodialysis patients were recruited. Their clinical data were measured before hemodialysis. Information was collected by an online self-reported questionnaire and medical record. Serum Mg 2+ was divided into three groups by tertiles. A score of AL greater than or equal to 3 was defined as high AL. A binary logistic regression model was applied to examine the relationship between serum Mg 2+ and AL. Results: A total of 1,222 patients undergoing hemodialysis were included, 60% of whom were males (733/1,222). The mean (standard deviation) age of patients was 55.90 (12.75). The median level of serum Mg 2+ was 1.22 mmol/L. The rate of high AL levels was 23.4%. Serum Mg 2+ was negatively correlated with body mass index, fasting blood glucose (Glu), and C-reactive protein and positively correlated with high-density lipoprotein, low-density lipoprotein, total cholesterol, diastolic blood pressure (DBP), and serum phosphorus. After adjusting for gender, anxiety, diabetes, family residence, lipid-lowering agents, antihypertensive medications, albumin, and Glu, the binary logistic regression model showed that patients with lower levels of serum Mg 2+ were more likely have high AL ( OR for the T1 group of serum Mg 2+ :1.945, 95% CI : 1.365–2.773, and OR for the T2 group of serum Mg 2+ :1.556, 95% CI : 1.099–2.201). Conclusion: Our data support the hypothesis that higher serum Mg 2+ concentrations may contribute to lower health risk in hemodialysis populations. Further randomized controlled trials and cohort studies are warranted to verify whether Mg 2+ supplementation could be part of routine examinations in hemodialysis populations.