Chromobox Homolog 8 (CBX8) in Human Tumor Carcinogenesis and Prognosis: A Pancancer Analysis Using Multiple Databases

Some emerging studies have suggested that chromobox homolog 8 (CBX8) may play a critical role in carcinogenesis and prognosis in human cancer. Based on The Cancer Genome Atlas (TCGA)’s available data and the Gene Expression Omnibus (GEO) database, we conducted a systematic analysis of the carcinogen...

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Published inFrontiers in genetics Vol. 12; p. 745277
Main Authors Shi, Dongjie, Ao, Lei, Yu, Hua, Xia, Yongzhi, Li, Juan, Zhong, Wenjie, Xia, Haijian
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 09.09.2021
Subjects
cancer
carcinogenesis
CBX8
Genetics
pancancer analysis
prognosis
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Summary:Some emerging studies have suggested that chromobox homolog 8 (CBX8) may play a critical role in carcinogenesis and prognosis in human cancer. Based on The Cancer Genome Atlas (TCGA)’s available data and the Gene Expression Omnibus (GEO) database, we conducted a systematic analysis of the carcinogenic effects of the CBX8 gene. We used TIMER2, GEPIA2, UALCAN, cBioPortal, Kaplan-Meier plotter, OncoLnc, STRING, HPA, and Oncomine data analysis websites and R data analysis software to analyze available data. The results show that the level of expression of CBX8 was significantly different among 27 different types of tumors and adjacent normal tissues. Moreover, we found that CBX8 expression had a close relationship with prognosis in some kinds of cancers. The phosphorylation level of some protein sites (such as S256) was significantly increased in tumors. CD8 + T-cell, B-cell and cancer-associated fibroblast infiltration levels were associated with CBX8 expression. The results of enrichment analysis indicated that the main biological activities of CBX8 are connected to gene transcription and repair of DNA damage. In conclusion, the level of expression of CBX8 was closely related to carcinogenesis and prognosis of some kinds of tumors, which needs further experimental verification.
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This article was submitted to Computational Genomics, a section of the journal Frontiers in Genetics
Edited by: Quan Zou, University of Electronic Science and Technology of China, China
Reviewed by: Tang Furong, Shenzhen Polytechnic, China; Changli Feng, Taishan University, China
These authors have contributed equally to this work and share first authorship
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2021.745277