Natural polymer-based scaffolds for soft tissue repair

Soft tissues such as skin, muscle, and tendon are easily damaged due to injury from physical activity and pathological lesions. For soft tissue repair and regeneration, biomaterials are often used to build scaffolds with appropriate structures and tailored functionalities that can support cell growt...

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Published inFrontiers in bioengineering and biotechnology Vol. 10; p. 954699
Main Authors Chen, Meiwen, Jiang, Rui, Deng, Niping, Zhao, Xiumin, Li, Xiangjuan, Guo, Chengchen
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 19.07.2022
Subjects
Bioengineering and Biotechnology
clinical translation
materials processing
natural polymers
scaffolds
soft tissue repair
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Summary:Soft tissues such as skin, muscle, and tendon are easily damaged due to injury from physical activity and pathological lesions. For soft tissue repair and regeneration, biomaterials are often used to build scaffolds with appropriate structures and tailored functionalities that can support cell growth and new tissue formation. Among all types of scaffolds, natural polymer-based scaffolds attract much attention due to their excellent biocompatibility and tunable mechanical properties. In this comprehensive mini-review, we summarize recent progress on natural polymer-based scaffolds for soft tissue repair, focusing on clinical translations and materials design. Furthermore, the limitations and challenges, such as unsatisfied mechanical properties and unfavorable biological responses, are discussed to advance the development of novel scaffolds for soft tissue repair and regeneration toward clinical translation.
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This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology
Reviewed by: Gajanan Arbade, National Centre for Cell Science, India
These authors have contributed equally to this work
Zhiwei Fang, Johns Hopkins University, United States
Edited by: Yongsheng Yu, Chinese Academy of Sciences, China
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.954699