Genetically determined resistance to 3-methylcholanthrene-induced lymphoma is expressed at the level of bone marrow-derived cells

• Published in: The Journal of experimental medicine Vol. 166; no. 2; pp. 565 - 570
• Main Authors: ISHIZAKA, S. T, LILLY, F
• Format: Journal Article
• Language: English
• Published: New York, NY Rockefeller University Press 01.08.1987; The Rockefeller University Press
• Subjects: Animals; Applied sciences; Bone Marrow Cells; Chimera; Drug Resistance; Exact sciences and technology; Lymphoma - chemically induced; Lymphoma - genetics; Methylcholanthrene; Mice; Mice, Inbred Strains; Other techniques and industries; Phenotype

Reciprocal bone marrow transfers were performed between mouse strains sensitive or resistant to 3-methylcholanthrene-induced thymic lymphoma. Sensitivity and resistance are properties inherent in bone marrow, and cannot be altered by maturation of marrow in an environment of the opposite phenotype.