Tumor pH-Responsive Nanocarriers With Light-Activatable Drug Release for Chemo-Photodynamic Therapy of Breast Cancer

Developing bioresponsive nanocarriers with particular tumor cell targeting and on-demand payload release has remained a great challenge for combined chemo-photodynamic therapy (chemo-PDT). In this study, an intelligent nanocarrier ( DA TAT-NP Ce6 ) responded to hierarchical endogenous tumor pH, and...

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Published inFrontiers in chemistry Vol. 10; p. 905645
Main Authors Zhang, Zhang, Gao, An, Sun, Chunyang
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 22.06.2022
Subjects
Chemistry
chemo-photodynamic combination therapy
nanocarrier
on-demand drug release
TAT presenting
tumor acidity responsive
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Summary:Developing bioresponsive nanocarriers with particular tumor cell targeting and on-demand payload release has remained a great challenge for combined chemo-photodynamic therapy (chemo-PDT). In this study, an intelligent nanocarrier ( DA TAT-NP Ce6 ) responded to hierarchical endogenous tumor pH, and an exogenous red light was developed through a simple mixed micelle approach. The outside TAT ligand was masked to prevent an unexpected interaction in blood circulation. Following the accumulation of DA TAT-NP Ce6 in tumor tissues, tumor acidity at pH ∼6.5 recovered its targeting ability via triggering DA moiety degradation. Furthermore, the cascaded chemo-PDT was accomplished through light-stimulated nanocarrier disassembly and doxorubicin (DOX) release. Taking advantage of stability and controllability, this work provides a facile approach to designing bioresponsive nanocarriers and represents a proof-of-concept combinatorial chemo-PDT treatment.
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Si Sun, Huazhong University of Science and Technology, China
These authors have contributed equally to this work
This article was submitted to Nanoscience, a section of the journal Frontiers in Chemistry
Edited by: Dalong Ni, Shanghai Jiao Tong University, China
Reviewed by: Meihua Lin, Shanghai Institute of Applied Physics (CAS), China
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2022.905645