From A to m6A: The Emerging Viral Epitranscriptome

There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. N6-methyladenosine (m6A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the regulation of the mRNA structure, stability, translation and nucl...

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Published inViruses Vol. 13; no. 6; p. 1049
Main Authors Baquero-Perez, Belinda, Geers, Daryl, Díez, Juana
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.06.2021
MDPI
Subjects
DNA viruses
epitranscriptomics
Genomes
m6A
Mass spectrometry
mRNA stability
N6-methyladenosine
Nuclear transport
Proteins
Review
RNA modification
RNA viruses
Roles
Scientific imaging
Stem cells
Transfer RNA
viral infection
Viral infections
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Summary:There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. N6-methyladenosine (m6A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the regulation of the mRNA structure, stability, translation and nuclear export. This modification is also found in viral RNA genomes and in viral mRNAs derived from both RNA and DNA viruses. A growing body of evidence indicates that m6A modifications play important roles in regulating viral replication by interacting with the cellular m6A machinery. In this review, we will exhaustively detail the current knowledge on m6A modification, with an emphasis on its function in virus biology.
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These authors contributed equally to this work.
ISSN:1999-4915
1999-4915
DOI:10.3390/v13061049