Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion

Hepatitis viruses are primary causative agents of hepatitis and represent a major source of public health problems in the world. The host innate immune system forms the first line of defense against hepatitis viruses. Hepatitis viruses are sensed by specific pathogen recognition receptors (PRRs) tha...

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Published inFrontiers in microbiology Vol. 12; p. 740464
Main Authors Xu, Chonghui, Chen, Jizheng, Chen, Xinwen
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 03.11.2021
Subjects
antiviral innate immunity
hepatitis virus
immune evasion
Microbiology
replication
viral infection
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Summary:Hepatitis viruses are primary causative agents of hepatitis and represent a major source of public health problems in the world. The host innate immune system forms the first line of defense against hepatitis viruses. Hepatitis viruses are sensed by specific pathogen recognition receptors (PRRs) that subsequently trigger the innate immune response and interferon (IFN) production. However, hepatitis viruses evade host immune surveillance via multiple strategies, which help compromise the innate immune response and create a favorable environment for viral replication. Therefore, this article reviews published findings regarding host innate immune sensing and response against hepatitis viruses. Furthermore, we also focus on how hepatitis viruses abrogate the antiviral effects of the host innate immune system.
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This article was submitted to Virology, a section of the journal Frontiers in Microbiology
Edited by: Xulin Chen, Jinan University, China
Reviewed by: Zongdi Feng, The Ohio State University, United States; Xiaoyong Zhang, Southern Medical University, China
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2021.740464